Evidence map›Paper›PMID 10454123›Full record

ReviewInternational journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity1999

The long isoform uncoupling protein-3 (UCP3L) in human energy homeostasis.

W K Chung, A Luke, R S Cooper, C Rotini, A Vidal-Puig, M Rosenbaum, D Gordon, S M Leal, S Caprio, R Goldsmith and 8 more

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 7 institutions in 2 countries.

W K ChungColumbia University, College of Physicians and Surgeons, Department of Pediatrics, New York, NY 10032, USA.
A Luke
R S Cooper
C Rotini
A Vidal-Puig
M Rosenbaum
D Gordon
S M Leal
S Caprio
R Goldsmith
A L Andreu
C Bruno
S DiMauro
M Heo
W L Lowe
B B Lowell
D B Allison
R L Leibel
Columbia University · USBeth Israel Deaconess Medical Center · USLoyola University Medical Center · USRockefeller University · USNorthwestern Medicine · USSt. Luke's-Roosevelt Hospital Center · USYale University · US

Funding

The molecular genetic analysis of human obesityR01DK052431 · NIDDK · ROCKEFELLER UNIVERSITY · PI CHUNG, WENDY K, LEIBEL, RUDOLPH L · 1996 to 2020
$11.6M
Glucose-Sensing by Neurons: Its Importance and the Role of UCP2R37DK053477 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI LOWELL, BRADFORD B · 2007 to 2016
$4.2M
NIDDK NIH HHS R01 DK052431NIDDK NIH HHS R37 DK053477
6 · The paper itself

Abstract

The biological role(s) proposed for UCP3 in energy homeostasis have been based primarily upon amino acid sequence homology to UCP1. Spontaneous mutations of UCP3> have been described in humans, but not in rodents. The functional consequences-or lack thereof-of these mutations in humans will be of great importance in elucidating the biology of this protein. The results of two such studies are summarized here.

Indexed as

AnimalsCarrier ProteinsEnergy MetabolismExonsHomeostasisHumansIon ChannelsMitochondriaMitochondrial ProteinsMutationObesityUncoupling Protein 3Carrier ProteinsIon ChannelsMitochondrial ProteinsUCP3 protein, humanUncoupling Protein 3

Identifiers

PMID10454123
PMCPMC6217808
OpenAlexW2322048522

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.