ArticleProceedings of the National Academy of Sciences of the United States of America1999
TCL1 oncogene expression in AIDS-related lymphomas and lymphoid tissues.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 78 citations in OpenAlex.
- Potential Pathogenic Impact of Cow's Milk Consumption and Bovine Milk-Derived Exosomal MicroRNAs in Diffuse Large B-Cell Lymphoma.International journal of molecular sciences · 2023Review
- Clinical and Molecular Properties of Human Immunodeficiency Virus-Related Diffuse Large B-Cell Lymphoma.Frontiers in oncology · 2021Review
- The TCL1 function revisited focusing on metabolic requirements of stemness.Cell cycle (Georgetown, Tex.) · 2019Review
- miR-181b as a therapeutic agent for chronic lymphocytic leukemia in the Eµ-TCL1 mouse model.Oncotarget · 2015Article
- Protooncogene TCL1b functions as an Akt kinase co-activator that exhibits oncogenic potency in vivo.Oncogenesis · 2013Article
- Candidate genes contributing to the aggressive phenotype of mantle cell lymphoma.Acta histochemica · 2011Article
- AID-induced genotoxic stress promotes B cell differentiation in the germinal center via ATM and LKB1 signaling.Molecular cell · 2010Article
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- Global DNA methylation profiling reveals silencing of a secreted form of Epha7 in mouse and human germinal center B-cell lymphomas.Oncogene · 2007Article
- TORC2 regulates germinal center repression of the TCL1 oncoprotein to promote B cell development and inhibit transformation.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Dysregulated TCL1 requires the germinal center and genome instability for mature B-cell transformation.Blood · 2006Article
- Virus-associated lymphomagenesis.International journal of biomedical science : IJBS · 2006Article
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- Differential gene expression in HIV/SIV-associated and spontaneous lymphomas.International journal of medical sciences · 2005Article
- An anti-apoptotic role for galectin-3 in diffuse large B-cell lymphomas.The American journal of pathology · 2004Article
- T cell leukemia I oncogene expression depends on the presence of Epstein-Barr virus in the virus-carrying Burkitt lymphoma lines.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- TCL1 participates in early embryonic development and is overexpressed in human seminomas.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
AIDS-related non-Hodgkin's lymphoma (AIDS NHL) comprises a diverse and heterogeneous group of high-grade B cell tumors. Certain classes of AIDS NHL are associated with alterations in oncogenes or tumor-suppressor genes or infections by oncogenic herpesviruses. However, the clinically significant class of AIDS NHL designated immunoblastic lymphoma plasmacytoid (AIDS IBLP) lacks any consistent genetic alterations. We identified the TCL1 oncogene from a set of AIDS IBLP-associated cDNA fragments generated by subtractive hybridization with non-AIDS IBLP. Aberrant TCL1 expression has been implicated in T cell leukemia/lymphoma development, and its expression also has been seen in many established B cell tumor lines. However, TCL1 expression has not been reported in AIDS NHL. We find that TCL1 is expressed in the majority of AIDS IBLP tumors examined. TCL1 protein expression is restricted to tumor cells in AIDS IBLP tissue samples analyzed with immunohistochemical staining. Hyperplastic lymph node and tonsil also exhibit strong TCL1 protein expression in mantle zone B cells and in rare interfollicular zone cells, whereas follicle-center B cells (centroblasts and centrocytes) show weaker expression. These results establish TCL1 as the most prevalent of all of the surveyed oncogenes associated with AIDS IBLP. They also indicate that abundant TCL1 expression in quiescent mantle zone B cells is down-regulated in activated germinal center follicular B cells in parallel to the known expression pattern of BCL-2. High-level expression in nonproliferating B cells suggests that TCL1 may function in protecting naïve preactivated B cells from apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.