ArticleProceedings of the National Academy of Sciences of the United States of America1999
Enhancer competition between H19 and Igf2 does not mediate their imprinting.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 92 citations in OpenAlex.
- The role of lncRNA H19 in tumorigenesis and drug resistance of human Cancers.Frontiers in genetics · 2022Review
- Adrenocortical Tumors in Children With Constitutive Chromosome 11p15 Paternal Uniparental Disomy: Implications for Diagnosis and Treatment.Frontiers in endocrinology · 2021Article
- Modeling human epigenetic disorders in mice: Beckwith-Wiedemann syndrome and Silver-Russell syndrome.Disease models & mechanisms · 2020Review
- Emerging role of long non-coding RNA in the development of gastric cancer.World journal of gastrointestinal oncology · 2018Review
- Long noncoding RNAs in the p53 network.Wiley interdisciplinary reviews. RNA · 2017Review
- The Interplay of LncRNA-H19 and Its Binding Partners in Physiological Process and Gastric Carcinogenesis.International journal of molecular sciences · 2017Review
- Humanized H19/Igf2 locus reveals diverged imprinting mechanism between mouse and human and reflects Silver-Russell syndrome phenotypes.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Genomic imprinting in mammals.Cold Spring Harbor perspectives in biology · 2014Review
- Conditional deletions refine the embryonic requirement for Dlk1.Mechanisms of development · 2013Article
- The human imprintome: regulatory mechanisms, methods of ascertainment, and roles in disease susceptibility.ILAR journal · 2012Review
- Non-coding RNAs as regulators of embryogenesis.Nature reviews. Genetics · 2011Review
- The function of non-coding RNAs in genomic imprinting.Development (Cambridge, England) · 2009Review
- Monoallelic gene expression in mammals.Chromosoma · 2009Review
- A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression.Molecular and cellular biology · 2008Article
- Imprinted noncoding RNAs.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Review
- Silencing by imprinted noncoding RNAs: is transcription the answer?Trends in genetics : TIG · 2007Review
- The imprinted Air ncRNA is an atypical RNAPII transcript that evades splicing and escapes nuclear export.The EMBO journal · 2006Article
- The Evf-2 noncoding RNA is transcribed from the Dlx-5/6 ultraconserved region and functions as a Dlx-2 transcriptional coactivator.Genes & development · 2006Article
- Developmental profile of H19 differentially methylated domain (DMD) deletion alleles reveals multiple roles of the DMD in regulating allelic expression and DNA methylation at the imprinted H19/Igf2 locus.Molecular and cellular biology · 2006Article
- Expression of a modified H19 RNA does not cause embryonic lethality in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The linked H19 and Igf2 genes on mouse distal chromosome 7 are subject to genomic imprinting. Competition between the promoters of the genes for transcription from shared enhancers has been proposed as an explanation for the coordinate expression and reciprocal imprinting of these two genes. To test this model, we have used Cre-loxP technology to generate in mice a conditional deletion of the H19 promoter and structural gene that leaves no transcription unit in the locus. Contrary to the prediction of enhancer competition we find that transcriptional activity from the H19 promoter is not required for the imprinted silencing of the Igf2 gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.