ArticleProceedings of the National Academy of Sciences of the United States of America1999
Fifty-million-year-old polymorphism at an immunoglobulin variable region gene locus in the rabbit evolutionary lineage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Molecular time estimates for the Lagomorpha diversification.PloS one · 2024Article
- Trans-specific polymorphism and the convergent evolution of supertypes in major histocompatibility complex class II genes in darters (Ecology and evolution · 2022Article
- An overview of the lagomorph immune system and its genetic diversity.Immunogenetics · 2016Review
- Identification of Allorecognition Loci in Neurospora crassa by Genomics and Evolutionary Approaches.Molecular biology and evolution · 2015Article
- Trans-Species Polymorphism in Immune Genes: General Pattern or MHC-Restricted Phenomenon?Journal of immunology research · 2015Review
- Evolution of dimorphisms of the proteasome subunit beta type 8 gene (PSMB8) in basal ray-finned fish.Immunogenetics · 2014Article
- Sequencing of modern Lepus VDJ genes shows that the usage of VHn genes has been retained in both Oryctolagus and Lepus that diverged 12 million years ago.Immunogenetics · 2013Article
- A novel rabbit monoclonal antibody platform to dissect the diverse repertoire of antibody epitopes for HIV-1 Env immunogen design.Journal of virology · 2013Article
- Molecular bases of genetic diversity and evolution of the immunoglobulin heavy chain variable region (IGHV) gene locus in leporids.Immunogenetics · 2011Review
- Transspecies dimorphic allelic lineages of the proteasome subunit beta-type 8 gene (PSMB8) in the teleost genus Oryzias.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Factors important in evolutionary shaping of immunoglobulin gene loci.Immunome research · 2010Article
- Evolutionary history of an MHC gene in two leporid species: characterisation of Mhc-DQA in the European brown hare and comparison with the European rabbit.Immunogenetics · 2009Article
- Article
- Balancing selection at a frog antimicrobial peptide locus: fluctuating immune effector alleles?Molecular biology and evolution · 2008Article
- Genetic contributions to the autoantibody profile in a rabbit model of Systemic Lupus Erythematosus (SLE).Veterinary immunology and immunopathology · 2008Article
- Conservation of inter-protein binding sites in RUSH and RFBP, an ATP11B isoform.Molecular and cellular endocrinology · 2008Article
- Genetic variation at chemokine receptor CCR5 in leporids: alteration at the 2nd extracellular domain by gene conversion with CCR2 in Oryctolagus, but not in Sylvilagus and Lepus species.Immunogenetics · 2006Article
- The evolution of the immunoglobulin heavy chain variable region (IgVH) in Leporids: an unusual case of transspecies polymorphism.Immunogenetics · 2005Article
- Dramatic variation of the vomeronasal pheromone receptor gene repertoire among five orders of placental and marsupial mammals.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Concerted and birth-and-death evolution of multigene families.Annual review of genetics · 2005Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Ig heavy chain variable region (V(H)) genes encode the antigen-binding regions of antibodies. The rabbit genome contains more than 100 V(H) genes, but only one (V(H)1) is preferentially used in the VDJ gene rearrangement. Three highly divergent alleles occur at this V(H)1 locus in most rabbit populations. These three V(H) alleles are also present in snowshoe hare populations, indicating that the polymorphism of the V(H)1 alleles is trans-specific. Here we report the results of a phylogenetic analysis of rabbit Ig germ-line V(H) genes (alleles) together with V(H) genes from humans and mice. We have found that all rabbit V(H) genes belong to one mammalian V(H) group (group C), which also includes various human and mouse V(H) genes. Using the rate of nucleotide substitution obtained from human and mouse V(H) sequences, we have estimated that the V(H)1 polymorphism in the rabbit lineage has been maintained for about 50 million years. This extremely long persistence of V(H)1 polymorphism is apparently caused by overdominant selection, though the real mechanism is unclear.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.