ArticleProceedings of the National Academy of Sciences of the United States of America1999
Immortalization of primary human keratinocytes by the helix-loop-helix protein, Id-1.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
58 citing papers in PubMed, 140 citations in OpenAlex.
- Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto-Placental Organ-on-Chip Platform.International journal of environmental research and public health · 2022Review
- Inhibitor of DNA binding in heart development and cardiovascular diseases.Cell communication and signaling : CCS · 2019Review
- Establishment of keratinocyte cell lines from human hair follicles.Scientific reports · 2018Article
- Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells.Frontiers of medicine · 2018Review
- The Role of p16International journal of molecular sciences · 2017Review
- A dual-reporter, diagnostic vector for prostate cancer detection and tumor imaging.Gene therapy · 2014Article
- ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities.Molecular therapy : the journal of the American Society of Gene Therapy · 2014Review
- Id1 and NF-κB promote the generation of CD133+ and BMI-1+ keratinocytes and the growth of xenograft tumors in mice.International journal of oncology · 2014Article
- Inhibitor of differentiation proteins do not influence prognosis of biliary tract cancer.World journal of gastroenterology · 2013Article
- DPY30 regulates pathways in cellular senescence through ID protein expression.The EMBO journal · 2013Article
- Decreased Expression of Inhibitor of DNA-binding (Id) Proteins and Vascular Endothelial Growth Factor and Increased Apoptosis in Ovarian Aging.Development & reproduction · 2013Article
- Id2 regulates the proliferation of squamous cell carcinoma in vitro via the NF-κB/Cyclin D1 pathway.Chinese journal of cancer · 2012Article
- Regulation of senescence in cancer and aging.Journal of aging research · 2011Article
- The role of inhibitor of DNA-binding (Id1) in hyperproliferation of keratinocytes: the pathological basis for middle ear cholesteatoma from chronic otitis media.Cell proliferation · 2010Article
- Inhibitor of differentiation 1 (ID1) promotes cell survival and proliferation of prostate epithelial cells.Cellular & molecular biology letters · 2010Article
- Tumor suppression by p53: making cells senescent.Histology and histopathology · 2010Review
- Role of inhibitor of DNA binding-1 protein is related to angiogenesis in the tumor advancement of uterine endometrial cancers.Experimental and therapeutic medicine · 2010Article
- Inhibitor of DNA binding-1 promotes the migration and proliferation of endothelial progenitor cells in vitro.Molecular and cellular biochemistry · 2010Article
- Elevated endogenous expression of the dominant negative basic helix-loop-helix protein ID1 correlates with significant centrosome abnormalities in human tumor cells.BMC cell biology · 2010Article
- Id1 promotes tumor cell migration in nonsmall cell lung cancers.Journal of oncology · 2010Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Basic helix-loop-helix (bHLH) DNA-binding proteins have been demonstrated to regulate tissue-specific transcription within multiple cell lineages. The Id family of helix-loop-helix proteins does not possess a basic DNA-binding domain and functions as a negative regulator of bHLH proteins. Overexpression of Id proteins within a variety of cell types has been shown to inhibit their ability to differentiate under appropriate conditions. We demonstrate that ectopic expression of Id-1 leads to activation of telomerase activity and immortalization of primary human keratinocytes. These immortalized cells have a decreased capacity to differentiate as well as activate phosphorylation of the retinoblastoma protein. Additionally, these cells acquire an impaired p53-mediated DNA-damage response as a late event in immortalization. We conclude that bHLH proteins play a pivotal role in regulating normal keratinocyte growth and differentiation, which can be disrupted by the immortalizing functions of Id-1 through activation of telomerase activity and inactivation of the retinoblastoma protein.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.