ArticleProceedings of the National Academy of Sciences of the United States of America1999
Basonuclin, a zinc finger protein of keratinocytes and reproductive germ cells, binds to the rRNA gene promoter.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 44 citations in OpenAlex.
- Natural Product Toosendanin Suppresses the Malignant Development of Skin Melanoma by Targeting BNC2 for Degradation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- BNC2 in Development and Disease: Regulatory Mechanisms and Translational Implications.Molecules (Basel, Switzerland) · 2026Review
- Substantial rDNA copy number reductions alter timing of development and produce variable tissue-specific phenotypes in C. elegans.Genetics · 2023Article
- Maternal effect factors that contribute to oocytes developmental competence: an update.Journal of assisted reproduction and genetics · 2022Review
- BNC1 Promotes Spermatogenesis by Regulating Transcription of Ybx2 and Papolb via Direct Binding to Their Promotor Elements.Reproductive sciences (Thousand Oaks, Calif.) · 2021Article
- Genomic Uniqueness of Local Sheep Breeds From Morocco.Frontiers in genetics · 2021Article
- Lysine-specific demethylase 2A enhances binding of various nuclear factors to CpG-rich genomic DNAs by action of its CXXC-PHD domain.Scientific reports · 2019Article
- Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development.European journal of human genetics : EJHG · 2011Article
- Basonuclin 2 has a function in the multiplication of embryonic craniofacial mesenchymal cells and is orthologous to disco proteins.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Basonuclin-null mutation impairs homeostasis and wound repair in mouse corneal epithelium.PloS one · 2007Article
- Article
- Investigation of the molecular profile of basal cell carcinoma using whole genome microarrays.Molecular cancer · 2006Article
- Search for basonuclin target genes.Biochemical and biophysical research communications · 2006Article
- Basonuclins 1 and 2, whose genes share a common origin, are proteins with widely different properties and functions.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Re-epithelialisation and the possible involvement of the transcription factor, basonuclin.International wound journal · 2004Review
- Basonuclin 2: an extremely conserved homolog of the zinc finger protein basonuclin.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- The gene expression sequence of radiated mucosa in an animal mucositis model.Cell proliferation · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Basonuclin is a protein containing three pairs of C(2)H(2) zinc fingers. The protein has been found in the basal (germinal) cell layer of stratified squamous epithelia, such as the epidermis, and in germ cells of the testis and ovary. We show here that the human protein has specific affinity for a segment of the promoter of the gene for rRNA. Basonuclin interacts with two separate parts of the promoter, each possessing dyad symmetry. The upstream part, but not the downstream part, is known to bind UBF1, a transcription factor for rDNA. Basonuclin is likely to be a cell-type-specific regulatory protein for rDNA transcription.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.