ArticleProceedings of the National Academy of Sciences of the United States of America1999
Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 80 citations in OpenAlex.
- Stomach at the crossroads: nuclear receptor signaling at the interface between what we are and what we eat.Physiological reviews · 2026Review
- Identification of CAND1 as a DNA-dependent protein kinase-regulated coactivator of androgen receptor and the ARv7 splice variant.PloS one · 2026Article
- Histone acetylation modulators in breast cancer.Breast cancer research : BCR · 2025Review
- Data mining historical Chinese medical recipe collections and nuclear receptor profiling identify plant fractions that modulate glucocorticoid receptor activity.Frontiers in pharmacology · 2025Article
- Trps1 acts as a regulator of Sf-1 transcription and testosterone synthesis in mouse Leydig cells.Cell biology and toxicology · 2023Article
- Simulating androgen receptor selection in designer yeast.Synthetic and systems biotechnology · 2022Article
- Arrest of WNT/β-catenin signaling enables the transition from pluripotent to differentiated germ cells in mouse ovaries.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- The Biological Significance of Targeting Acetylation-Mediated Gene Regulation for Designing New Mechanistic Tools and Potential Therapeutics.Biomolecules · 2021Review
- Selection and Application of DNA Aptamer Against Oncogene Amplified in Breast Cancer 1.Journal of molecular evolution · 2015Article
- H4K12ac is regulated by estrogen receptor-alpha and is associated with BRD4 function and inducible transcription.Oncotarget · 2015Article
- Role of Nuclear Receptors in Central Nervous System Development and Associated Diseases.Journal of experimental neuroscience · 2015Review
- The enhanced antiproliferative response to combined treatment of trichostatin A with raloxifene in MCF-7 breast cancer cells and its relevance to estrogen receptor β expression.Molecular and cellular biochemistry · 2012Article
- Acquisition of sexual receptivity: roles of chromatin acetylation, estrogen receptor-alpha, and ovarian hormones.Endocrinology · 2011Article
- Ligand-dependent degradation of SRC-1 is pivotal for progesterone receptor transcriptional activity.Molecular endocrinology (Baltimore, Md.) · 2011Article
- Pre-receptor regulation of the androgen receptor.Molecular and cellular endocrinology · 2008Review
- PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription.Journal of molecular signaling · 2007Article
- Signaling within a coactivator complex: methylation of SRC-3/AIB1 is a molecular switch for complex disassembly.Molecular and cellular biology · 2006Article
- Nuclear receptor coactivators function in estrogen receptor- and progestin receptor-dependent aspects of sexual behavior in female rats.Hormones and behavior · 2006Article
- ERalpha and ERbeta expression and transcriptional activity are differentially regulated by HDAC inhibitors.Oncogene · 2006Article
- Human SWI/SNF generates abundant, structurally altered dinucleosomes on polynucleosomal templates.Molecular and cellular biology · 2005Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Progesterone receptor (PR) functions as a transcription factor that modulates the transcription of target genes in response to progesterone and other signals. The transcriptional activity of PR requires the involvement of coactivators such as steroid receptor coactivator-1 (SRC-1). To dissect the role of SRC-1 in PR transactivation, we established an in vitro transcription system with chromatin templates, in which PR induced transcription in a ligand-dependent and PRE-dependent manner. In the presence of ligand, purified PR bound to chromatin templates, resulting in chromatin remodeling. With this system, the ability of purified SRC-1 to act as a coactivator of PR was examined. SRC-1 potentiated transcription by ligand-activated PR, whereas it had no effect on transcription in the absence of ligands. As SRC-1 possesses intrinsic histone acetyltransferase activity, we tested the role of acetylation in PR-mediated transcription by using a histone deacetylase inhibitor, trichostatin A (TSA). We found that addition of TSA strongly enhanced PR-dependent transcription on chromatin but not on naked DNA template, and the effects of SRC-1 and TSA on PR transactivation were partially redundant. In addition, SRC-1 was able to potentiate PR transactivation with nonchromatin templates. Thus, our results substantiate a two-step mechanism whereby recruitment of coactivator SRC-1 by the ligand-activated PR in vivo leads to (i) chromatin remodeling through histone acetylation and (ii) recruitment/stabilization of the preinitiation complex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.