ArticleThe Journal of experimental medicine1999
Direct evidence for thymic function in adult humans.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
55 citing papers in PubMed, 233 citations in OpenAlex.
- Impact of growth hormone (GH) deficiency and GH replacement upon thymus function in adult patients.PloS one · 2009Trial
- Growth hormone enhances thymic function in HIV-1-infected adults.The Journal of clinical investigation · 2008Trial
- Heterogeneity of thymic output in the elderly and its association with sex and smoking.JCI insight · 2025Article
- eHealth mindfulness-based music therapy for patients undergoing allogeneic hematopoietic stem cell transplantation: A pilot randomized controlled trial protocol.Contemporary clinical trials · 2024Article
- Multi-omic analyses in immune cell development with lessons learned from T cell development.Frontiers in cell and developmental biology · 2023Review
- Correlation between thymic output and disease severity in critically ill COVID-19 patients: extended abstract.Mediastinum (Hong Kong, China) · 2022Article
- Protective reactive thymus hyperplasia in COVID-19 acute respiratory distress syndrome.Critical care (London, England) · 2021Observational
- Radiotherapy-related lymphopenia in patients with advanced non-small cell lung cancer receiving palliative radiotherapy.Clinical and translational radiation oncology · 2020Article
- Article
- Superior immune reconstitution using Treg-expanded donor cells versus PTCy treatment in preclinical HSCT models.JCI insight · 2018Article
- The Great Recession and Immune Function.The Russell Sage Foundation journal of the social sciences : RSF · 2018Article
- Single-Cell Analysis Identifies Thymic Maturation Delay in Growth-Restricted Neonatal Mice.Frontiers in immunology · 2018Article
- Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity.JCI insight · 2017Article
- Decreases in thymopoiesis of astronauts returning from space flight.JCI insight · 2016Article
- Population Distributions of Thymic Function in Adults: Variation by Sociodemographic Characteristics and Health Status.Biodemography and social biology · 2016Article
- Diversity and clonal selection in the human T-cell repertoire.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Mechanisms shaping the naïve T cell repertoire in the elderly - thymic involution or peripheral homeostatic proliferation?Experimental gerontology · 2014Review
- The evolving art of hematopoietic stem cell transplantation: translational research in post-transplant immune reconstitution and immunosuppression.Immunologic research · 2013Review
- The past, present, and future of immune repertoire biology - the rise of next-generation repertoire analysis.Frontiers in immunology · 2013Review
- Naive T-cells in myelodysplastic syndrome display intrinsic human telomerase reverse transcriptase (hTERT) deficiency.Leukemia · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
The understanding of human thymic function and evaluation of its contribution to T cell homeostasis are matters of great importance. Here we report the development of a novel assay to quantitate the frequency and diversity of recent thymic emigrants (RTEs) in the peripheral blood of humans. Such cells were defined by the presence of T cell receptor (TCR) rearrangement deletion circles (DCs), episomal byproducts of TCR-beta V(D)J rearrangement. DCs were detected in T cells in the thymus, cord blood, and adult peripheral blood. In the peripheral blood of adults aged 22 to 76 years, their frequency was highest in the CD4(+)CD45RA(+) CD62L(+) subpopulation of naive T cells. TCR DCs were also observed in other subpopulations of peripheral blood T cells, including those with the CD4(+)CD45RO(-)CD62L(+) and CD4(+)CD45RO(+)CD62L(+) phenotypes. RTEs were observed to have more than one Vbeta rearrangement, suggesting that replenishment of the repertoire in the adult is at least oligoclonal. These results demonstrate that the normal adult thymus continues to contribute, even in older individuals, a diverse set of new T cells to the peripheral circulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.