ArticleThe Journal of experimental medicine1999
B cell antigen receptor specificity and surface density together determine B-1 versus B-2 cell development.
Article in The Journal of experimental medicine, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 214 citations in OpenAlex.
- Building an Interleukin-10-Producing Identity: How B Cells Acquire Interleukin-10 Competence and How Plasma Cell Differentiation Consolidates This Program.Immunological reviews · 2026Review
- The multilayered identity of B cell memory.Cellular & molecular immunology · 2026Review
- B-1 lymphocytes in adipose tissue as innate modulators of inflammation linked to cardiometabolic disease.Immunological reviews · 2024Review
- CK2β-regulated signaling controls B cell differentiation and function.Frontiers in immunology · 2022Article
- H3K36 methyltransferase NSD1 is essential for normal B1 and B2 cell development and germinal center formation.Frontiers in immunology · 2022Article
- Replacement of TCR Dβ With Immunoglobulin DFrontiers in immunology · 2020Article
- B-1a cells acquire their unique characteristics by bypassing the pre-BCR selection stage.Nature communications · 2019Article
- One-step generation of monoclonal B cell receptor mice capable of isotype switching and somatic hypermutation.The Journal of experimental medicine · 2018Article
- IgH isotype-specific B cell receptor expression influences B cell fate.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Article
- To B-1 or not to B-1.Nature immunology · 2017Article
- Positive Regulation of Lyn Kinase by CD148 Is Required for B Cell Receptor Signaling in B1 but Not B2 B Cells.Immunity · 2016Article
- Ikaros Is a Negative Regulator of B1 Cell Development and Function.The Journal of biological chemistry · 2016Article
- Restricted, canonical, stereotyped and convergent immunoglobulin responses.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Natural IgM is produced by CD5- plasma cells that occupy a distinct survival niche in bone marrow.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Positive selection of natural poly-reactive B cells in the periphery occurs independent of heavy chain allelic inclusion.PloS one · 2015Article
- Endocytosis and recycling of immune complexes by follicular dendritic cells enhances B cell antigen binding and activation.Immunity · 2013Article
- Human B-1 cells take the stage.Annals of the New York Academy of Sciences · 2013Review
- Expression of plasma cell alloantigen 1 defines layered development of B-1a B-cell subsets with distinct innate-like functions.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice expressing the immunoglobulin (Ig) heavy (H) chain variable (V) region from a rearranged V(H)12 gene inserted into the IgH locus generate predominantly B-1 cells, whereas expression of two other V(H) region transgenes (V(H)B1-8 and V(H)glD42) leads to the almost exclusive generation of conventional, or B-2, cells. To determine the developmental potential of B cells bearing two distinct B cell antigen receptors (BCRs), one favoring B-1 and the other favoring B-2 cell development, we crossed V(H)12 insertion mice with mice bearing either V(H)B1-8 or V(H)glD42. B cells coexpressing V(H)12 and one of the other V(H) genes are readily detected in the double IgH insertion mice, and are of the B-2 phenotype. In mice coexpressing V(H)12, V(H)B1-8 and a transgenic kappa chain able to pair with both H chains, double H chain-expressing B-2 cells, and B-1 cells that have lost V(H)B1-8 are generated, whereas V(H)B1-8 single producers are undetectable. These data suggest that B-1 but not B-2 cells are selected by antigenic stimuli in whose delivery BCR specificity and surface density are of critical importance.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.