ArticleJournal of clinical microbiology1999
Infection with agents of human granulocytic ehrlichiosis, lyme disease, and babesiosis in wild white-footed mice (Peromyscus leucopus) in Connecticut.
Article in Journal of clinical microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 114 citations in OpenAlex.
- Differential Impact of Simultaneous or Sequential Coinfections WithInternational journal of microbiology · 2025Article
- The known unknowns of Powassan virus ecology.Journal of medical entomology · 2023Review
- Prevalence of five human pathogens in host-seeking Ixodes scapularis and Ixodes pacificus by region, state, and county in the contiguous United States generated through national tick surveillance.Ticks and tick-borne diseases · 2023Article
- Inter-annual variation in prevalence of Borrelia burgdorferi sensu stricto and Anaplasma phagocytophilum in host-seeking Ixodes scapularis (Acari: Ixodidae) at long-term surveillance sites in the upper midwestern United States: Implications for public health practice.Ticks and tick-borne diseases · 2022Article
- The environment, the tick, and the pathogen - It is an ensemble.Frontiers in cellular and infection microbiology · 2022Review
- The absence of the drhm gene is not a marker for human-pathogenicity in European Anaplasma phagocytophilum strains.Parasites & vectors · 2020Article
- Field evaluation of a novel oral reservoir-targeted vaccine against Borrelia burgdorferi utilizing an inactivated whole-cell bacterial antigen expression vehicle.Experimental & applied acarology · 2020Article
- Splenic infarction in babesiosis: A rare presentation.Clinical case reports · 2019Article
- Investigating disease severity in an animal model of concurrent babesiosis and Lyme disease.International journal for parasitology · 2019Review
- Prevalence and distribution of seven human pathogens in host-seeking Ixodes scapularis (Acari: Ixodidae) nymphs in Minnesota, USA.Ticks and tick-borne diseases · 2018Article
- Experimental evaluation of Peromyscus leucopus as a reservoir host of the Ehrlichia muris-like agent.Parasites & vectors · 2017Article
- Human granulocytic anaplasmosis.Infectious disease clinics of North America · 2015Review
- Analysis of the population structure of Anaplasma phagocytophilum using multilocus sequence typing.PloS one · 2014Article
- Borrelia burgdorferi promotes the establishment of Babesia microti in the northeastern United States.PloS one · 2014Article
- Natural history of Zoonotic Babesia: Role of wildlife reservoirs.International journal for parasitology. Parasites and wildlife · 2013Review
- Anaplasma phagocytophilum strains from voles and shrews exhibit specific ankA gene sequences.BMC veterinary research · 2013Article
- Expression profiling of lymph node cells from deer mice infected with Andes virus.BMC immunology · 2013Article
- Anaplasma phagocytophilum--a widespread multi-host pathogen with highly adaptive strategies.Frontiers in cellular and infection microbiology · 2013Review
- Elimination of Borrelia burgdorferi and Anaplasma phagocytophilum in rodent reservoirs and Ixodes scapularis ticks using a doxycycline hyclate-laden bait.The American journal of tropical medicine and hygiene · 2011Article
- Coinfections acquired from ixodes ticks.Clinical microbiology reviews · 2006Review
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
White-footed mice, Peromyscus leucopus, were captured in southern Connecticut during 1997 and 1998 to determine the prevalence of infections caused by granulocytic Ehrlichia sp., Borrelia burgdorferi, and Babesia microti. Of the 50 mice captured and recaptured, 25 of 47 (53.2%) and 23 of 48 (47.9%) contained antibodies to the BDS or NCH-1 Ehrlichia strains, respectively, as determined by indirect fluorescent antibody (IFA) staining methods. The majority (83.3%) of 48 mice also contained antibodies to B. burgdorferi, as determined by enzyme-linked immunosorbent assay. Moreover, 20 of 26 (76.9%) contained antibodies to B. microti by IFA staining methods. In nested PCR tests using the 16S rRNA gene, the DNA of the human granulocytic ehrlichiosis (HGE) agent was detected in 17 of 47 mice (36.2%), but only 4 (23.5%) of these 17 mice were PCR positive at each capture. Antibody-positive reactions to granulocytic Ehrlichia sp. organisms were detected in 17 of 23 (73. 9%) of the PCR-positive mice. The sequences from PCR products from nine positive blood samples were identical to the HGE agent. Ehrlichia spp. were cultured from three of five mice captured in April 1998, including one that was PCR positive in April 1997. In addition, 2 of 14 larval Ixodes scapularis pools, which were attached to two PCR-positive mice, contained DNA of the HGE agent. A high percentage of white-footed mice are infected or have been infected naturally by the HGE agent with low-level persistent infection or frequent reinfection in some individual mice. However, the changes noted in the presence of DNA and antibodies in repeated blood and serum samples from individual mice over several months of field collection suggests that infection with granulocytic Ehrlichia is transient in most wild P. leucopus.
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