ArticleJournal of clinical microbiology1999
Elucidating the origins of nosocomial infections with Candida albicans by DNA fingerprinting with the complex probe Ca3.
Article in Journal of clinical microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 106 citations in OpenAlex.
- Bacterial metabolites induce cell wall remodeling, antifungal resistance, and immune recognition of commensal fungi.Current biology : CB · 2026Article
- Antimicrobial Peptides: Avant-Garde Antifungal Agents to Fight against Medically ImportantPharmaceutics · 2023Review
- Microbiota signatures associated with invasiveFrontiers in cellular and infection microbiology · 2023Article
- Friendly fungi: symbiosis with commensal Candida albicans.Trends in immunology · 2022Review
- Candida albicans colonization of the gastrointestinal tract: A double-edged sword.PLoS pathogens · 2021Review
- The Glyoxylate Cycle Is Involved in White-Opaque Switching inJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- Evaluation of Polymorphic Locus Sequence Typing for Candida glabrata Epidemiology.Journal of clinical microbiology · 2016Article
- Clonal Strain Persistence of Candida albicans Isolates from Chronic Mucocutaneous Candidiasis Patients.PloS one · 2016Article
- Molecular Diversity of Candida albicans Isolated from Immunocompromised Patients, Based on MLST Method.Iranian journal of public health · 2015Article
- Clinical and microbiological investigation of fungemia from four hospitals in China.Mycopathologia · 2015Article
- Candida colonization index and subsequent infection in critically ill surgical patients: 20 years later.Intensive care medicine · 2014Review
- Management of invasive candidiasis in nonneutropenic ICU patients.Therapeutic advances in infectious disease · 2014Review
- Resistance of Candida spp. to antifungal drugs in the ICU: where are we now?Intensive care medicine · 2014Review
- Investigation of a cluster of Candida albicans invasive Candidiasis in a neonatal intensive care unit by pulsed-field gel electrophoresis.TheScientificWorldJournal · 2012Article
- Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype.Journal of clinical microbiology · 2011Article
- Multilocus sequence typing for Candida albicans isolates from candidemic patients: comparison with Southern blot hybridization and pulsed-field gel electrophoresis analysis.The Korean journal of laboratory medicine · 2011Article
- Genomic plasticity of the human fungal pathogen Candida albicans.Eukaryotic cell · 2010Review
- Canadian clinical practice guidelines for invasive candidiasis in adults.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2010Article
- SSD1 is integral to host defense peptide resistance in Candida albicans.Eukaryotic cell · 2008Article
Corrections and comments
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Authors and funding
14 authors at 8 institutions in 2 countries.
Funding
Abstract
Computer-assisted DNA fingerprinting with the complex probe Ca3 has been used to analyze the relatedness of isolates collected from individuals with nosocomial bloodstream infections (BSIs) and hospital care workers (HCWs) in the surgical and neonatal intensive care units (ICUs) of four hospitals. The results demonstrate that for the majority of patients (90%), isolates collected from commensal sites before and after collection of a BSI isolate were highly similar or identical to the BSI isolate. In addition, the average similarity coefficient for BSI isolates was similar to that for unrelated control isolates. However, the cluster characteristics of BSI isolates in dendrograms generated for each hospital compared to those of unrelated control isolates in a dendrogram demonstrated a higher degree of clustering of the former. In addition, a higher degree of clustering was observed in mixed dendrograms for HCV isolates and BSI isolates for each of the four test hospitals. In most cases, HCW isolates from an ICU were collected after the related BSI isolate, but in a few cases, the reverse was true. Although the results demonstrate that single, dominant endemic strains are not responsible for nosocomial BSIs in neonatal ICUs and surgical ICUs, they suggest that multiple endemic strains may be responsible for a significant number of cases. The results also suggest that cross-contamination occurs between patients and HCWs and between HCWs in the same ICU and in different ICUs. The temporal sequence of isolation also suggests that in the majority of cases HCWs are contaminated by isolates from colonized patients, but in a significant minority, the reverse is true. The results of this study provide the framework for a strategy for more definitive testing of the origins of Candida albicans strains responsible for nosocomial infections.
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