ArticleImmunology1999
Role of mitogen-activated protein kinases in activation-induced apoptosis of T cells.
Article in Immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 54 citations in OpenAlex.
- ERK1/2 activation in anti-inflammatory effects and underlying signaling mechanisms.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Monovalent Anti-CD3 Antibodies Effectively Eliminate the TCR-Positive Fraction of TCR-Deleted Allogeneic CAR-T Cells to Prevent GVHD.Immune network · 2024Article
- A novel trivalent non-Fc anti-CD3 Collabody preferentially induces Th1 cell apoptosisFrontiers in immunology · 2023Article
- JNK1 and ERK1/2 modulate lymphocyte homeostasis via BIM and DRP1 upon AICD induction.Cell death and differentiation · 2020Article
- Proteomic Analysis of Two Weight Classes of Mule Duck "Frontiers in physiology · 2020Article
- The Role of Reactive Oxygen Species in Regulating T Cell-mediated Immunity and Disease.Immune network · 2018Review
- Vitamin K1 exerts antiproliferative effects and induces apoptosis in three differently graded human colon cancer cell lines.BioMed research international · 2015Article
- The role of Raf-1 kinase in diabetic retinopathy.Expert opinion on therapeutic targets · 2011Review
- Galectin-8 induces apoptosis in Jurkat T cells by phosphatidic acid-mediated ERK1/2 activation supported by protein kinase A down-regulation.The Journal of biological chemistry · 2009Article
- Regulated expression of galectin-1 during T-cell activation involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase and p70S6 kinase.Molecular and cellular biochemistry · 2004Article
- A role for MAP kinase in the antitumor activity of a nucleoside analog.Cancer gene therapy · 2002Article
- Effects of heavy metals on mitogen-activated protein kinase pathways.Environmental health and preventive medicine · 2002Article
- Critical role of extracellular signal-regulated kinase (ERK) phosphorylation in novel vitamin K analog-induced cell death.Japanese journal of cancer research : Gann · 2000Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
A member of the mitogen-activated protein (MAP) kinase family, Jun N-terminal kinase (JNK), has been implicated in regulating apoptosis in various cell types. We have investigated the requirement for another type of MAP kinase, extracellular signal-regulated protein kinase (ERK) in activation-induced cell death (AICD) of T cells. AICD is the process by which recently activated T cells undergo apoptosis when restimulated through the T-cell antigen receptor. Here we show that both JNK and ERK are activated rapidly upon T-cell receptor (TCR) ligation prior to the onset of AICD. A chemical inhibitor of ERK activation, PD 098059, inhibits ERK activation and apoptosis, while JNK activation is not inhibited. This suggests that JNK activation is not sufficient for apoptosis. TCR cross-linking induces expression of the apoptosis-inducing factor, Fas ligand (FasL), and its expression correlates with ERK activation. In addition, apoptosis induced by direct ligation of the Fas receptor by anti-Fas antibody is not associated with ERK activation and is not inhibited by PD 098059. These data suggest that ERK activation is an early event during T-cell apoptosis induced by antigen-receptor ligation, and is not involved in apoptosis per se but in the expression of FasL. MAP kinase family members may be similarly involved in inducing apoptosis signals in other cell types.
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Registered trials
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