ArticleImmunology1999
Natural polyreactive immunoglobulin A antibodies produced in mouse Peyer's patches.
Article in Immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Peptidoglycan fromBioscience of microbiota, food and health · 2026Article
- Role of cellular effectors in the induction and maintenance of IgA responses leading to protective immunity against enteric bacterial pathogens.Frontiers in immunology · 2024Review
- The Underappreciated Role of Secretory IgA in IBD.Inflammatory bowel diseases · 2023Article
- Article
- Genetic Background Affects the Mucosal Secretory IgA Levels, Parasite Burden, Lung Inflammation, and Mouse Susceptibility toInfection and immunity · 2022Article
- Mycobiota-induced IgA antibodies regulate fungal commensalism in the gut and are dysregulated in Crohn's disease.Nature microbiology · 2021Article
- IgA Vasculitis: Etiology, Treatment, Biomarkers and Epigenetic Changes.International journal of molecular sciences · 2021Review
- Article
- Is There a Role for Natural Antibodies in Rejection Following Transplantation?Transplantation · 2019Review
- IgA Responses to Microbiota.Immunity · 2018Review
- Gut microbiota utilize immunoglobulin A for mucosal colonization.Science (New York, N.Y.) · 2018Article
- Biodegradable Chitosan Decreases the Immune Response to Trichinella spiralis in Mice.Molecules (Basel, Switzerland) · 2017Article
- Natural polyreactive IgA antibodies coat the intestinal microbiota.Science (New York, N.Y.) · 2017Article
- Characterizing the interactions between a naturally primed immunoglobulin A and its conserved Bacteroides thetaiotaomicron species-specific epitope in gnotobiotic mice.The Journal of biological chemistry · 2015Article
- Antibody repertoire diversification through VH gene replacement in mice cloned from an IgA plasma cell.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Immune-directed support of rich microbial communities in the gut has ancient roots.Developmental and comparative immunology · 2014Review
- Putting J chain back on the map: how might its expression define plasma cell development?Journal of immunology (Baltimore, Md. : 1950) · 2014Review
- New concepts in the generation and functions of IgA.Nature reviews. Immunology · 2012Review
- Polyreactive antibodies in adaptive immune responses to viruses.Cellular and molecular life sciences : CMLS · 2012Review
- M cell-targeted ocular immunization: effect on immunoglobulins in tears, feces, and serum.Investigative ophthalmology & visual science · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the biological function of natural immunoglobulin A (IgA) antibodies in Peyer's patches (PP), we generated IgA monoclonal antibody (mAb) clones from the PP of normal, unimmunized, specific pathogen-free BALB/c mice and examined their reactivities by enzyme-linked immunosorbent assay (ELISA). Many of these antibodies reacted with more than one antigen examined, suggesting that they were polyreactive Abs. Two mAbs agglutinated several different strains of commensal bacteria isolated from mice. To examine the genetic features of these polyreactive mAbs, the VH genes of seven different IgA mAbs were sequenced. The VH genes from the VGAM, J558 and 7183 families were compared with sequence from the mAbs with distinct VDJ rearrangements. One of the mAbs that agglutinated bacteria was encoded by a germline VH gene, but the VH region of the other polyreactive mAbs contained between seven and 11 mutated sites. No indication of antigenic selection was observed in the pattern of these mutated sites. Our results show that polyreactive IgA Abs are present in PP as a part of the normal B-cell repertoire. These polyreactive Abs may establish a natural immune homeostasis, and function as a polyreactive sensor to detect pathogenic invasion and to control immune response in the gut.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.