Trial reportGut1999
Cholinergic effects on human gastric motility.
Trial report in Gut, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 112 citations in OpenAlex.
- Electrogastrography measurement systems and analysis methods used in clinical practice and research: comprehensive review.Frontiers in medicine · 2024Pooled it
- A pharmacological challenge predicts reversible rectal sensorimotor dysfunctions in women with fecal incontinence.Neurogastroenterology and motility · 2018Trial
- Comparison of selective M3 and nonselective muscarinic receptor antagonists on gastrointestinal transit and bowel habits in humans.American journal of physiology. Gastrointestinal and liver physiology · 2010Trial
- Concurrent administration of donepezil HCl and levodopa/carbidopa in patients with Parkinson's disease: assessment of pharmacokinetic changes and safety following multiple oral doses.British journal of clinical pharmacology · 2004Trial
- Consensus on the Management of Anesthetic Agents During Digestive Motility Measurements and Proposal of a Standardized Protocol for Anesthesia (French Neuro Gastroenterology Group GFNG and Committee of Anesthetic French Experts).Neurogastroenterology and motility · 2026Article
- Management of Gastrointestinal Symptoms in Parkinson's Disease.Journal of central nervous system disease · 2025Review
- Extensive scintigraphic gastric motor function testing with concurrent symptom recording predicts prospectively measured daily dyspeptic symptoms.Neurogastroenterology and motility · 2024Article
- Reexamining Compliance with Gastric Emptying Scintigraphy Guidelines: An Updated Analysis of the Intersocietal Accreditation Commission Database.Journal of nuclear medicine technology · 2024Article
- Ultrasonographic evaluation of the effects of azithromycin on antral motility and gastric emptying in healthy cats.Journal of veterinary internal medicine · 2022Article
- Gastroparesis in Parkinson Disease: Pathophysiology, and Clinical Management.Brain sciences · 2021Review
- Dextran Sodium Sulphate-Induced Gastrointestinal Injury Further Aggravates the Impact of Galantamine on the Gastric Myoelectric Activity in Experimental Pigs.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Gastrointestinal dysfunction in the synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Review
- Article
- Disorders of gastrointestinal hypomotility.F1000Research · 2016Review
- From ischochymia to gastroparesis: proposed mechanisms and preferred management of dyspepsia over the centuries.Digestive diseases and sciences · 2014Article
- A two-component nonlinear mixed effects model for longitudinal data, with application to gastric emptying studies.Statistics in medicine · 2010Article
- Comparison of the effect of azithromycin versus erythromycin on antroduodenal pressure profiles of patients with chronic functional gastrointestinal pain and gastroparesis.Digestive diseases and sciences · 2010Article
- A novel method for study of gastric mechanical functions in conscious mice.Digestive diseases and sciences · 2009Article
- Interstitial cells of Cajal mediate mechanosensitive responses in the stomach.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- A human PBPK model for ethanol describing inhibition of gastric motility.Journal of molecular histology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCholinergic regulation of chronotropic (frequency) and inotropic (force) aspects of antral contractility and how these impact on gastric emptying are not well delineated.
aimsTo determine the effects of cholinergic stimulation and inhibition on myoelectric, contractile, and emptying parameters of gastric motility.
methodsTen normal subjects underwent three studies each, using simultaneous electrogastrography (EGG), antroduodenal manometry, and gastric emptying with dynamic antral scintigraphy (DAS). After 30 minutes of baseline fasting manometry and EGG, subjects received saline intravenously, atropine (0.6 mg then 0.25 mg/hour intravenously), or bethanechol (5 mg subcutaneously). This was followed by another 30 minutes' recording and by three hours of postprandial recording after ingestion of a technetium-99m labelled solid meal.
resultsDuring fasting, atropine decreased, whereas bethanechol increased, the antral manometric motility index and EGG power. Postprandially, atropine decreased the amplitude of antral contractions by DAS, decreased the postprandial antral manometric motility index, and slowed gastric emptying. Atropine caused a slight increase in postprandial frequency of antral contractions by DAS and gastric myoelectrical activity by EGG. Bethanechol slightly increased the amplitude, but slightly decreased the frequency of antral contractions by DAS and decreased the frequency of gastric myoelectrical activity by EGG, with no significant increase in the motility index or gastric emptying.
conclusionsCholinergic antagonism with atropine reduces antral contractility and slows gastric emptying. Cholinergic stimulation with bethanechol increases antral contractility, but decreases the frequency of antral contractions, without altering the antral motility index or gastric emptying.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.