ArticleClinical and experimental immunology1999
Immunogenetic risk factors for anti-neutrophil cytoplasmic antibody (ANCA)-associated systemic vasculitis.
Article in Clinical and experimental immunology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Systematic review of associations between HLA and renal function.International journal of immunogenetics · 2022Pooled it
- CTLA-4 and TNF-α promoter-308 A/G polymorphisms and ANCA-associated vasculitis susceptibility: a meta-analysis.Molecular biology reports · 2012Pooled it
- Updates of ocular involvement in granulomatosis with polyangiitis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Review
- Epidemiology and genetics of granulomatosis with polyangiitis.Rheumatology international · 2021Review
- Associations between human leukocyte antigens and renal function.Scientific reports · 2021Article
- LTBJournal of lipid research · 2020Article
- The role of common protective alleles HLA-DRB1*13 among systemic autoimmune diseases.Genes and immunity · 2017Review
- Extranodal NK/T-cell Lymphoma, Nasal Type Accompanied by PR3-ANCA-associated Glomerulonephritis.Internal medicine (Tokyo, Japan) · 2017Article
- Clinical association of mixed connective tissue disease and granulomatosis with polyangiitis: a case report and systematic screening of anti-U1RNP and anti-PR3 auto-antibody double positivity in ten European hospitals.Immunologic research · 2016Article
- Article
- Neutrophil MiRNA-128-3p is Decreased During Active Phase of Granulo-matosis with Polyangiitis.Current genomics · 2015Article
- Genetics of ANCA-associated Vasculitides.Current rheumatology reports · 2014Review
- Pathogenesis of ANCA-associated vasculitis.Current rheumatology reports · 2012Review
- Association of HLA genes with clinical outcomes of ANCA-associated vasculitis.Clinical journal of the American Society of Nephrology : CJASN · 2012Article
- Genetics of microscopic polyangiitis in the Japanese population.Annals of vascular diseases · 2012Article
- Pathogenesis of ANCA-associated vasculitis.Rheumatic diseases clinics of North America · 2010Review
- Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients.Genes and immunity · 2009Article
- ANCA patients have T cells responsive to complementary PR-3 antigen.Kidney international · 2008Article
- On the Wegener granulomatosis associated region on chromosome 6p21.3.BMC medical genetics · 2006Article
- Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in Japanese.Genes and immunity · 2006Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wegener's granulomatosis (WG) and microscopic polyangiitis are systemic autoimmune diseases characterized by the presence of ANCA in the sera of patients. Little is known about the aetiologic factors and genetic predisposition as well as the pathogenesis of these disease entities. A slightly decreased representation of HLA-DRB1*13 and HLA-DQB1*0603 individuals was observed in our cohort of ANCA-associated systemic vasculitis (AASV) patients compared with controls. In addition, HLA-DRB1*04 individuals were over-represented in a subgroup of patients with WG in end-stage renal disease as a result of renal vasculitis. In order to identify other genes relevant for these diseases, we investigated highly polymorphic markers in the vicinity of several immunorelevant genes, i.e. tumour necrosis factor (TNF)alpha, IL-2, IL-5 receptor alpha (IL-5RA), in a group of 102 patients with AASV and compared the representation with controls. Furthermore, functional polymorphisms were directly analysed in the promotor region of TNFalpha as well as in the coding region of the FcgammaIIRA genes. Polymorphisms of the TNFalpha promotor (TNF-308) as well as in the FcgammaIIRA gene were excluded as risk factors for the disease in our cohort. No major phenotype distribution differences were observed between patients and controls for the IL-2 and IL-5RA microsatellites. Most importantly, several haplotypes on chromosome 6p appeared strongly associated with proteinase 3 (PR3)-ANCA+ AASV. Thus, as in other autoimmune diseases, different predisposing factors play differential aetiopathogenic roles in various groups of AASV patients.
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