ArticleThe Journal of cell biology1999
Two compartments for insulin-stimulated exocytosis in 3T3-L1 adipocytes defined by endogenous ACRP30 and GLUT4.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 174 citations in OpenAlex.
- The effects of irbesartan and telmisartan on metabolic parameters and blood pressure in obese, insulin resistant, hypertensive patients.Journal of endocrinological investigation · 2006Trial
- The antihypertensive effect of irbesartan in spontaneously hypertensive rats is associated with improvement of the leptin-adiponectin imbalance.Adipocyte · 2021Article
- Relationship between Plasma Adiponectin Level and Corrected QT Interval in Smoker and Non-smoker Adult Male Subjects.Journal of the ASEAN Federation of Endocrine Societies · 2020Article
- Interorgan communication by exosomes, adipose tissue, and adiponectin in metabolic syndrome.The Journal of clinical investigation · 2019Review
- Adrenergic stimulation of adiponectin secretion in visceral mouse adipocytes is blunted in high-fat diet induced obesity.Scientific reports · 2019Article
- CaJournal of cell science · 2019Article
- The Mechanism of Phillyrin from the Leaves ofBioMed research international · 2019Article
- Mathematical modeling of white adipocyte exocytosis predicts adiponectin secretion and quantifies the rates of vesicle exo- and endocytosis.The Journal of biological chemistry · 2017Article
- Normal menstrual cycle steroid hormones variation does not affect the blood levels of total adiponectin and its multimer forms.Journal of clinical & translational endocrinology · 2015Article
- Cooling reduces cAMP-stimulated exocytosis and adiponectin secretion at a Ca2+-dependent step in 3T3-L1 adipocytes.PloS one · 2015Article
- Smoking and diabetes: is the association mediated by adiponectin, leptin, or C-reactive protein?Journal of epidemiology · 2015Article
- PKA-independent cAMP stimulation of white adipocyte exocytosis and adipokine secretion: modulations by Ca2+ and ATP.The Journal of physiology · 2014Article
- Increased adiponectin associated with poor survival in hepatocellular carcinoma.Journal of gastroenterology · 2014Article
- Ultrastructural localization of adiponectin protein in vasculature of normal and atherosclerotic mice.Scientific reports · 2014Article
- Endoproteolytic cleavage of TUG protein regulates GLUT4 glucose transporter translocation.The Journal of biological chemistry · 2012Article
- Ficus deltoidea: A Potential Alternative Medicine for Diabetes Mellitus.Evidence-based complementary and alternative medicine : eCAM · 2012 · on this mapArticle
- Negative regulation of adiponectin secretion by receptor interacting protein 140 (RIP140).Cellular signalling · 2012Article
- Regulation of adiponectin production by insulin: interactions with tumor necrosis factor-α and interleukin-6.American journal of physiology. Endocrinology and metabolism · 2011Article
- Adipokines as novel biomarkers and regulators of the metabolic syndrome.Annals of the New York Academy of Sciences · 2010Review
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Insulin stimulates adipose cells both to secrete proteins and to translocate the GLUT4 glucose transporter from an intracellular compartment to the plasma membrane. We demonstrate that whereas insulin stimulation of 3T3-L1 adipocytes has no effect on secretion of the alpha3 chain of type VI collagen, secretion of the protein hormone adipocyte complement related protein of 30 kD (ACRP30) is markedly enhanced. Like GLUT4, regulated exocytosis of ACRP30 appears to require phosphatidylinositol-3-kinase activity, since insulin-stimulated ACRP30 secretion is blocked by pharmacologic inhibitors of this enzyme. Thus, 3T3-L1 adipocytes possess a regulated secretory compartment containing ACRP30. Whether GLUT4 recycles to such a compartment has been controversial. We present deconvolution immunofluorescence microscopy data demonstrating that the subcellular distributions of ACRP30 and GLUT4 are distinct and nonoverlapping; in contrast, those of GLUT4 and the transferrin receptor overlap. Together with supporting evidence that GLUT4 does not recycle to a secretory compartment via the trans-Golgi network, we conclude that there are at least two compartments that undergo insulin-stimulated exocytosis in 3T3-L1 adipocytes: one for ACRP30 secretion and one for GLUT4 translocation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.