ArticleThe Journal of cell biology1999
Localization in the nucleolus and coiled bodies of protein subunits of the ribonucleoprotein ribonuclease P.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed.
- RNase MRP subunit composition and role in 40S ribosome biogenesis.Nature structural & molecular biology · 2026Article
- Coevolution of RNA and protein subunits in RNase P and RNase MRP, two RNA processing enzymes.The Journal of biological chemistry · 2024Review
- Human RNase P: overview of a ribonuclease of interrelated molecular networks and gene-targeting systems.RNA (New York, N.Y.) · 2023Review
- The axis of complement C1 and nucleolus in antinuclear autoimmunity.Frontiers in immunology · 2023Review
- The Dynamic Network of RNP RNase P Subunits.International journal of molecular sciences · 2021Review
- RNA polymerase III and antiviral innate immune response.Transcription · 2021Review
- Mapping and Engineering Functional Domains of the Assembly-Activating Protein of Adeno-associated Viruses.Journal of virology · 2018Article
- The Nucleolus: In Genome Maintenance and Repair.International journal of molecular sciences · 2017Review
- A role of human RNase P subunits, Rpp29 and Rpp21, in homology directed-repair of double-strand breaks.Scientific reports · 2017Article
- RNase P protein subunit Rpp29 represses histone H3.3 nucleosome deposition.Molecular biology of the cell · 2016Article
- Functional ultrastructure of the plant nucleolus.Protoplasma · 2014Review
- Global genome organization mediated by RNA polymerase III-transcribed genes in fission yeast.Gene · 2012Review
- tRNA biology charges to the front.Genes & development · 2010Review
- Ribosomal protein L7Ae is a subunit of archaeal RNase P.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Nucleolar retention of a translational C/EBPalpha isoform stimulates rDNA transcription and cell size.The EMBO journal · 2010Article
- Footprinting analysis demonstrates extensive similarity between eukaryotic RNase P and RNase MRP holoenzymes.RNA (New York, N.Y.) · 2008Article
- The role of the plant nucleolus in pre-mRNA processing.Current topics in microbiology and immunology · 2008Review
- Human RNase P: a tRNA-processing enzyme and transcription factor.Nucleic acids research · 2007Review
- The nucleolus: a model for the organization of nuclear functions.Histochemistry and cell biology · 2006Review
- Potential roles for ubiquitin and the proteasome during ribosome biogenesis.Molecular and cellular biology · 2006Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
The precise location of the tRNA processing ribonucleoprotein ribonuclease P (RNase P) and the mechanism of its intranuclear distribution have not been completely delineated. We show that three protein subunits of human RNase P (Rpp), Rpp14, Rpp29 and Rpp38, are found in the nucleolus and that each can localize a reporter protein to nucleoli of cells in tissue culture. In contrast to Rpp38, which is uniformly distributed in nucleoli, Rpp14 and Rpp29 are confined to the dense fibrillar component. Rpp29 and Rpp38 possess functional, yet distinct domains required for subnucleolar localization. The subunit Rpp14 lacks such a domain and appears to be dependent on a piggyback process to reach the nucleolus. Biochemical analysis suggests that catalytically active RNase P exists in the nucleolus. We also provide evidence that Rpp29 and Rpp38 reside in coiled bodies, organelles that are implicated in the biogenesis of several other small nuclear ribonucleoproteins required for processing of precursor mRNA. Because some protein subunits of RNase P are shared by the ribosomal RNA processing ribonucleoprotein RNase MRP, these two evolutionary related holoenzymes may share common intranuclear localization and assembly pathways to coordinate the processing of tRNA and rRNA precursors.
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