ArticleInflammation1999
Role of chemotactic factors in neutrophil activation after thermal injury in rats.
Article in Inflammation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Metabolic implications of severe burn injuries and their management: a systematic review of the literature.World journal of surgery · 2008Pooled it
- Dermal Nanoemulsion Treatment Reduces Burn Wound Conversion and Improves Skin Healing in a Porcine Model of Thermal Burn Injury.Journal of burn care & research : official publication of the American Burn Association · 2021Article
- Thermal Burn Injury Generates Bioactive Microvesicles: Evidence for a Novel Transport Mechanism for the Lipid Mediator Platelet-Activating Factor (PAF) That Involves Subcellular Particles and the PAF Receptor.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- Myosin light chain kinase signaling in endothelial barrier dysfunction.Medicinal research reviews · 2013Review
- Aging and the pathogenic response to burn.Aging and disease · 2012Article
- Topical nanoemulsion therapy reduces bacterial wound infection and inflammation after burn injury.Surgery · 2010Article
- Myosin light chain kinase in microvascular endothelial barrier function.Cardiovascular research · 2010Review
- Wound trauma mediated inflammatory signaling attenuates a tissue regenerative response in MRL/MpJ mice.Journal of inflammation (London, England) · 2010Article
- Extracorporeal shock wave therapy suppresses the early proinflammatory immune response to a severe cutaneous burn injury.International wound journal · 2009Article
- Aging and animal models of systemic insult: trauma, burn, and sepsis.Shock (Augusta, Ga.) · 2009Review
- Nutritional and pharmacological modulation of the metabolic response of severely burned patients: review of the literature (part 1).Annals of burns and fire disasters · 2008Article
- Functional significance of inducible nitric oxide synthase induction and protein nitration in the thermally injured cutaneous microvasculature.The American journal of pathology · 2003Article
- Delayed topical p38 MAPK inhibition attenuates full-thickness burn wound inflammatory signaling.Journal of burn care & research : official publication of the American Burn AssociationArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Acute thermal trauma is well known to produce evidence of a "systemic inflammatory response" in vivo, as manifested by evidence of complement activation, appearance in plasma of a variety of inflammatory factors, and development of multi-organ injury. The current studies were focused on acute thermal injury of rat skin and factors responsible for accompanying activation of blood neutrophils. Acute thermal injury of rat skin resulted in a time-dependent loss of L-selectin and up-regulation of Mac-1 (CD11b/CD18) on blood neutrophils, with no changes in LFA-1 (CD11a/CD18). The loss of L-selectin was prevented by blockade of C5a but not by blockade of the alpha-chemokine, macrophage inflammatory protein-2 (MIP-2). C5a, the alpha chemokines, MIP-2 and keratinocyte-derived cytokine (KC), and platelet activating factor (PAF) contributed to up-regulation of blood neutrophil Mac-1. Blocking interventions against these mediators also blunted the degree of neutropenia developing after thermal trauma. These data suggest that activation of blood neutrophils after thermal trauma is related to the role of several chemotactic mediators. These studies may provide clues regarding factors responsible for development of the "systemic inflammatory response syndrome" after thermal injury in the experimental model employed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.