ArticleAmerican journal of human genetics1999
Replication of linkage studies of complex traits: an examination of variation in location estimates.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Meta-analyses of genome-wide linkage scans of anxiety-related phenotypes.European journal of human genetics : EJHG · 2012Pooled it
- Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2007Pooled it
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.American journal of human genetics · 2003Pooled it
- Regional meta-analysis of published data supports linkage of autism with markers on chromosome 7.Molecular psychiatry · 2002Pooled it
- A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.Molecular psychiatry · 2005Trial
- Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families.Molecular psychiatry · 2005Trial
- Replication of 1q42 linkage in Finnish schizophrenia pedigrees.Molecular psychiatry · 2004Trial
- Epistatic Gene-Based Interaction Analyses for Glaucoma in eMERGE and NEIGHBOR Consortium.PLoS genetics · 2016Article
- Major Loci on Chromosomes 8q and 3q Control Interferon γ Production Triggered by Bacillus Calmette-Guerin and 6-kDa Early Secretory Antigen Target, Respectively, in Various Populations.The Journal of infectious diseases · 2016Article
- Tuberculin skin test negativity is under tight genetic control of chromosomal region 11p14-15 in settings with different tuberculosis endemicities.The Journal of infectious diseases · 2015Article
- Genetic and functional evidence for a locus controlling otitis media at chromosome 10q26.3.BMC medical genetics · 2014Article
- The genetics of major depression.Neuron · 2014Review
- Identification of a major locus, TNF1, that controls BCG-triggered tumor necrosis factor production by leukocytes in an area hyperendemic for tuberculosis.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2013Article
- Functional polymorphisms of the coagulation factor II gene (F2) and susceptibility to systemic lupus erythematosus.The Journal of rheumatology · 2011Article
- Tests for genetic interactions in type 1 diabetes: linkage and stratification analyses of 4,422 affected sib-pairs.Diabetes · 2011Article
- Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2010Article
- A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.Addiction biology · 2010Review
- Linkage of atopic dermatitis to chromosomes 4q22, 3p24 and 3q21.Human genetics · 2009Article
- Fine-mapping of candidate region in Amish and Ashkenazi families confirms linkage of refractive error to a QTL on 1p34-p36.Molecular vision · 2009Article
- Agreement among type 2 diabetes linkage studies but a poor correlation with results from genome-wide association studies.Diabetologia · 2009Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In linkage studies, independent replication of positive findings is crucial in order to distinguish between true positives and false positives. Recently, the following question has arisen in linkage studies of complex traits: at what distance do we reject the hypothesis that two location estimates in a genomic region represent the same gene? Here we attempt to address this question. Sampling distributions for location estimates were constructed by computer simulation. The conditions for simulation were chosen to reflect features of "typical" complex traits, including incomplete penetrance, phenocopies, and genetic heterogeneity. Our findings, which bear on what is considered a replication in linkage studies of complex traits, suggest that, even with relatively large numbers of multiplex families, chance variation in the location estimate is substantial. In addition, we report evidence that, for the conditions studied here, the standard error of a location estimate is a function of the magnitude of the expected LOD score.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.