ReviewGene expression1999
Induction of metallothionein by stress and its molecular mechanisms.
Review in Gene expression, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Metallothionein and neurodegenerative diseases.Neural regeneration research · 2026Article
- Small heat shock protein HSPB5 uses disorder to bind zinc with high affinity.bioRxiv : the preprint server for biology · 2025Article
- Oxidative stress and neuroimmune proteins in a mouse model of autism.Cell stress & chaperones · 2023Article
- Stress responses, M2 macrophages, and a distinct microbial signature in fatal intestinal acute graft-versus-host disease.JCI insight · 2019Article
- Adrenergic and glucocorticoid receptor antagonists reduce ozone-induced lung injury and inflammation.Toxicology and applied pharmacology · 2018Article
- Brain and Hepatic Mt mRNA Is Reduced in Response to Mild Energy Restriction and n-3 Polyunsaturated Fatty Acid Deficiency in Juvenile Rats.Nutrients · 2017Article
- Psychological stress induced zinc accumulation and up-regulation of ZIP14 and metallothionein in rat liver.BMC gastroenterology · 2014Article
- Glucocorticoids regulate metallothionein-1/2 expression in rat choroid plexus: effects on apoptosis.Molecular and cellular biochemistry · 2013Article
- Role of metallothioneins in benign and malignant thyroid lesions.Thyroid research · 2012Article
- Article
- Metallothionein (MT) -I and MT-II expression are induced and cause zinc sequestration in the liver after brain injury.PloS one · 2012Article
- Metallothionein and brain inflammation.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2011Review
- Metallothionein and the biology of aging.Ageing research reviews · 2011Review
- Proteomic analysis of chronic restraint stress-induced Gan (肝)-stagnancy syndrome in rats.Chinese journal of integrative medicine · 2010Article
- Article
- Metallothioneins and brain injury: What transgenic mice tell us.Environmental health and preventive medicine · 2004Article
- Activity of metal-responsive transcription factor 1 by toxic heavy metals and H2O2 in vitro is modulated by metallothionein.Molecular and cellular biology · 2003Article
- Metallothioneins (I+II) and thyroid-thymus axis efficiency in old mice: role of corticosterone and zinc supply.Mechanisms of ageing and development · 2002Article
- Killifish metallothionein messenger RNA expression following temperature perturbation and cadmium exposure.Cell stress & chaperones · 2001Article
- Downregulation of constitutive and heavy metal-induced metallothionein-I expression by nuclear factor I.Gene expression · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
This article describes the effect of restraint stress or social reorganization stress on the induction of metallothionein (MT) in the liver, heart, lung, and spleen. Both MT-I and MT-II mRNA were elevated as much as 30-fold following just 12 h (one cycle) of restraint stress. The amount of MT protein also increased following stress. The MT induction was the highest in the liver, followed by the lung, heart, and spleen. MT-I induction was also observed in the fore, mid, and hind regions of the brain whereas the brain-specific MT-III gene was not activated by stress. The increase in MT mRNA correlated well with the rise in stress-induced serum corticosterone. The induction occurred at the transcriptional level and was mediated essentially by the activation of glucocorticoid receptor. The MT mRNA returned to the control level after nine cycles of stress. Exposure of these habituated mice to a different type of stress (treatment with heavy metals such as cadmium or zinc sulfate) led to further MT induction. Because heavy metals induced MT via activation of the factor MTF-1, distinct molecular mechanisms should be responsible for the activation of MT promoter by different inducers.
Indexed as
Identifiers
10440231PMC6174668W2417206285What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.