ArticleJournal of the American Society for Mass Spectrometry1999
Matrix-assisted laser desorption ionization hydrogen/deuterium exchange studies to probe peptide conformational changes.
Article in Journal of the American Society for Mass Spectrometry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 49 citations in OpenAlex.
- Detection of structural and conformational changes in ALS-causing mutant profilin-1 with hydrogen/deuterium exchange mass spectrometry and bioinformatics techniques.Metabolic brain disease · 2022Article
- Nonresonant femtosecond laser vaporization of aqueous protein preserves folded structure.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- A Study of Ion-Neutral Collision Cross Section Values for Low Charge States of Peptides, Proteins, and Peptide/Protein Complexes.International journal of mass spectrometry · 2010Article
- Factors that influence helical preferences for singly charged gas-phase peptide ions: the effects of multiple potential charge-carrying sites.The journal of physical chemistry. B · 2010Article
- A mechanistic study of the H/D exchange reactions of protonated arginine and arginine-containing di- and tripeptides.Journal of the American Society for Mass Spectrometry · 2009Article
- Steroid and protein ligand binding to cytochrome P450 46A1 as assessed by hydrogen-deuterium exchange and mass spectrometry.Biochemistry · 2009Article
- The structure of gas-phase bradykinin fragment 1-5 (RPPGF) ions: an ion mobility spectrometry and H/D exchange ion-molecule reaction chemistry study.Journal of the American Society for Mass Spectrometry · 2005Article
- Hydrogen/deuterium exchange on yeast ATPase supramolecular protein complex analyzed at high sensitivity by MALDI mass spectrometry.Journal of the American Society for Mass Spectrometry · 2003Article
- Hydrogen/deuterium exchange of hydrophobic peptides in model membranes by electrospray ionization mass spectrometry.Journal of the American Society for Mass Spectrometry · 2002Article
- Hydrogen-deuterium exchange at non-labile sites: a new reaction facet with broad implications for structural and dynamic determinations.Journal of the American Society for Mass Spectrometry · 2001Article
- The methanol-induced conformational transitions of beta-lactoglobulin, cytochrome c, and ubiquitin at low pH: a study by electrospray ionization mass spectrometry.Journal of the American Society for Mass Spectrometry · 2001Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hydrogen/deuterium (H/D) exchange chemistry monitored by matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is used to study solution phase conformational changes of bradykinin, alpha-melanocyte stimulating hormone, and melittin as water is added to methanol-d4, acetonitrile, and isopropanol-d8 solutions. The results are interpreted in terms of a preference for the peptides to acquire more compact conformations in organic solvents as compared to the random conformations. Our interpretation is supported by circular dichroism spectra of the peptides in the same solvent systems and by previously published structural data for the peptides. These results demonstrate the utility of MALDI-TOF as a method to monitor the H/D exchange chemistry of peptides and investigations of solution-phase conformations of biomolecules.
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Registered trials
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