Evidence map›Paper›PMID 10438885›Full record

ArticleJournal of virology1999

Middle T antigen activation of signal transduction pathways does not overcome p53-mediated growth arrest.

J Doherty, R Freund

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Natural biology of polyomavirus middle T antigen.Microbiology and molecular biology reviews : MMBR · 2001
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J DohertyMolecular and Cell Biology Program, University of Maryland, Baltimore, Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
R Freund
University of Maryland, Baltimore · US

Funding

TISSUE SPECIFIC TUMOR INDUCTION BY POLYOMAVIRUSR29CA063111 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI CERNY, JAN · 1995 to 1999
–
NCI NIH HHS CA63111
6 · The paper itself

Abstract

Polyomavirus middle T antigen does not overcome p53-mediated G(1) arrest in mouse embryo fibroblasts. Middle T antigen still associates with the signaling molecules phosphatidylinositol 3-kinase and SHC and activates the transcriptional activity of c-Myc and AP1 in p53-arrested cells. Examination of cell cycle regulatory proteins indicated that p53 does not interfere with these mitogenic signals but acts later in the G(1) phase of the cell cycle.

Indexed as

Adaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportSignal TransductionActivating Transcription Factor 4AnimalsAntigens, Polyomavirus TransformingCell DivisionCell LineCyclin-Dependent Kinase Inhibitor p21CyclinsFibroblastsMiceMitogensPhosphatidylinositol 3-KinasesProteinsProto-Oncogene Proteins c-mycActivating Transcription Factor 4Adaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAntigens, Polyomavirus TransformingAtf4 protein, mouseCdkn1a protein, mouseCyclin-Dependent Kinase Inhibitor p21CyclinsMitogensPhosphatidylinositol 3-KinasesProteinsProto-Oncogene Proteins c-mycProto-Oncogene Proteins pp60(c-src)Shc1 protein, mouseShc Signaling Adaptor ProteinsSrc Homology 2 Domain-Containing, Transforming Protein 1Trans-ActivatorsTranscription Factor AP-1Tumor Suppressor Protein p53

Identifiers

PMID10438885
PMCPMC104322
OpenAlexW2125396440

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.