ArticleJournal of virology1999
Fine mapping of the friend retrovirus resistance gene, Rfv3, on mouse chromosome 15.
Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Mouse APOBEC3 Restriction of Retroviruses.Viruses · 2020Review
- Friend retrovirus studies reveal complex interactions between intrinsic, innate and adaptive immunity.FEMS microbiology reviews · 2019Review
- Antibody-mediated immune control of a retrovirus does not require the microbiota.Journal of virology · 2014Article
- Humoral immunity in the Friend retrovirus infection model.Immunologic research · 2013Review
- Innate immune sensing of retroviral infection via Toll-like receptor 7 occurs upon viral entry.Immunity · 2011Article
- Persistent Friend virus replication and disease in Apobec3-deficient mice expressing functional B-cell-activating factor receptor.Journal of virology · 2011Article
- Innate retroviral restriction by Apobec3 promotes antibody affinity maturation in vivo.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Adaptive evolution of Mus Apobec3 includes retroviral insertion and positive selection at two clusters of residues flanking the substrate groove.PLoS pathogens · 2010Article
- Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected mice.Journal of virology · 2010Article
- Retroviral immunology: lessons from a mouse model.Immunologic research · 2009Article
- Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivo.Journal of virology · 2008Article
- Apobec3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection.Science (New York, N.Y.) · 2008Article
- Replication of beta- and gammaretroviruses is restricted in I/LnJ mice via the same genetic mechanism.Journal of virology · 2008Article
- Species-specific restriction of apobec3-mediated hypermutation.Journal of virology · 2008Article
- Identification of quantitative trait loci for susceptibility to mouse adenovirus type 1.Journal of virology · 2005Article
- Unique resistance of I/LnJ mice to a retrovirus is due to sustained interferon gamma-dependent production of virus-neutralizing antibodies.The Journal of experimental medicine · 2003Article
- Genetic control of neuroadapted sindbis virus replication in female mice maps to chromosome 2 and associates with paralysis and mortality.Journal of virology · 2001Article
Corrections and comments
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Authors and funding
12 authors at 6 institutions in 1 country.
Funding
Abstract
Rfv3 is a host resistance gene that operates through an unknown mechanism to control the development of the virus-neutralizing antibody response required for recovery from infection with Friend retrovirus. The Rfv3 gene was previously mapped to an approximately 20-centimorgan (cM) region of chromosome 15. More refined mapping was not possible, due to a lack of microsatellite markers and leakiness in the Rfv3 phenotype, which prevented definitive phenotyping of individual recombinant mice. In the present study, we overcame these difficulties by taking advantage of seven new microsatellite markers in the Rfv3 region and by using progeny tests to accurately determine the Rfv3 phenotype of recombinant mice. Detailed linkage analysis of relevant crossovers narrowed the location of Rfv3 to a 0.83-cM region. Mapping of closely linked genes in an interspecific backcross panel allowed us to exclude two previous candidate genes, Ly6 and Wnt7b. These studies also showed for the first time that the Hsf1 gene maps to the Rfv3-linked cluster of genes including Il2rb, Il3rb, and Pdgfb. This localization of Rfv3 to a region of less than 1 cM now makes it feasible to attempt the cloning of Rfv3 by physical methods.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.