Evidence map›Paper›PMID 10438795›Full record

ArticleJournal of virology1999

Respiratory syncytial virus G and/or SH protein alters Th1 cytokines, natural killer cells, and neutrophils responding to pulmonary infection in BALB/c mice.

R A Tripp, D Moore, L Jones, W Sullender, J Winter, L J Anderson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 156 citations in OpenAlex.

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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

R A TrippDivision of Viral and Rickettsial Diseases, National Center of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA. rgt3@cdc.gov
D Moore
L Jones
W Sullender
J Winter
L J Anderson
National Center for Infectious Diseases · USCenters for Disease Control and Prevention · USUniversity of Alabama · US

Funding

MECHANISM OF RSV VACCINE IMMUNOPOTENTIATIONR01AI037197 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SULLENDER, WAYNE M · 1994 to 1997
–
RESPIRATORY SYNCYTIAL VIRUS ATTACHMENT PROTEIN DIVERSITYR29AI033425 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SULLENDER, WAYNE M · 1993 to 1997
–
NIAID NIH HHS AI33425NIAID NIH HHS AI37197
6 · The paper itself

Abstract

BALB/c mice sensitized to vaccinia virus expressed G protein of respiratory syncytial virus (RSV) develop a Th2-type cytokine response and pulmonary eosinophilia when challenged with live RSV. In this study, BALB/c mice were immunized or challenged with an RSV mutant lacking the G and SH proteins or with DNA vaccines coding for RSV G or F protein. F or G protein DNA vaccines were capable of sensitizing for pulmonary eosinophilia. The absence of the G and/or SH protein in the infecting virus resulted in a consistent increase both in pulmonary natural killer cells and in gamma interferon and tumor necrosis factor expression, as well as, with primary infection, a variable increase in neutrophils and CD11b(+) cells. The development of pulmonary eosinophilia in formalin-inactivated RSV-vaccinated mice required the presence of the G and/or SH protein in the challenge virus. These data show that G and/or SH protein has a marked impact on the inflammatory and innate immune response to RSV infection.

Indexed as

HN ProteinAnimalsChlorocebus aethiopsCytokinesDisease Models, AnimalFemaleHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHumansKiller Cells, NaturalLung DiseasesMiceMice, Inbred BALB CNeutrophilsRespiratory Syncytial Virus, HumanRespiratory Syncytial Virus Infectionsattachment protein GCytokinesHistocompatibility Antigens Class IHistocompatibility Antigens Class IIHN ProteinViral Envelope ProteinsViral Proteins

Identifiers

PMID10438795
PMCPMC104227
OpenAlexW2102809170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.