ArticleJournal of bacteriology1999
Transcriptional analysis of the hmw gene cluster of Mycoplasma pneumoniae.
Article in Journal of bacteriology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Mycoplasma genitalium: whole genome sequence analysis, recombination and population structure.BMC genomics · 2017Article
- Integrated Information and Prospects for Gliding Mechanism of the Pathogenic Bacterium Mycoplasma pneumoniae.Frontiers in microbiology · 2016Article
- Intrinsic terminators in Mycoplasma hyopneumoniae transcription.BMC genomics · 2015Article
- Vaccination of BALB/c mice with an avirulent Mycoplasma pneumoniae P30 mutant results in disease exacerbation upon challenge with a virulent strain.Infection and immunity · 2012Article
- Mycoplasma hyopneumoniae transcription unit organization: genome survey and prediction.DNA research : an international journal for rapid publication of reports on genes and genomes · 2011Article
- Insights into the function of Mycoplasma pneumoniae protein P30 from orthologous gene replacement.Microbiology (Reading, England) · 2011Article
- A trigger enzyme in Mycoplasma pneumoniae: impact of the glycerophosphodiesterase GlpQ on virulence and gene expression.PLoS pathogens · 2011Article
- Transposon mutagenesis identifies genes associated with Mycoplasma pneumoniae gliding motility.Journal of bacteriology · 2006Article
- Transcriptional heat shock response in the smallest known self-replicating cell, Mycoplasma genitalium.Journal of bacteriology · 2006Article
- Probing in vivo promoter activities in Mycoplasma pneumoniae: a system for generation of single-copy reporter constructs.Applied and environmental microbiology · 2006Article
- Mutant analysis reveals a specific requirement for protein P30 in Mycoplasma pneumoniae gliding motility.Journal of bacteriology · 2005Article
- Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae.Journal of bacteriology · 2005Article
- Transcriptional analysis of the conserved ftsZ gene cluster in Mycoplasma genitalium and Mycoplasma pneumoniae.Journal of bacteriology · 2005Article
- Characterization of a Mycoplasma pneumoniae hmw3 mutant: implications for attachment organelle assembly.Journal of bacteriology · 2002Article
- Stability and subcellular localization of cytadherence-associated protein P65 in Mycoplasma pneumoniae.Journal of bacteriology · 2001Article
- Transcription in Mycoplasma pneumoniae.Nucleic acids research · 2000Article
- Molecular characterization of the Mycoplasma gallisepticum pvpA gene which encodes a putative variable cytadhesin protein.Infection and immunity · 2000Article
- Identification of a small RNA within the pdh gene cluster of Mycoplasma pneumoniae and Mycoplasma genitalium.Journal of bacteriology · 2000Article
- Identification and complementation of frameshift mutations associated with loss of cytadherence in Mycoplasma pneumoniae.Journal of bacteriology · 1999Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Mycoplasma pneumoniae adherence to host cells is a multifactorial process that requires the cytadhesin P1 and additional accessory proteins. The hmw gene cluster consists of the genes p30, hmw3, and hmw1, the products of which are known to be essential for cytadherence, the rpsD gene, and six open reading frames of unknown function. Putative transcriptional terminators flank this locus, raising the possibility that these genes are expressed as a single transcriptional unit. However, S1 nuclease protection and primer extension experiments identified probable transcriptional start sites upstream of the p32, p21, p50, and rpsD genes. Each was preceded at the appropriate spacing by the -10-like sequence TTAAAATT, but the -35 regions were not conserved. Analysis of the M. pneumoniae genome sequence indicated that this promoter-like sequence is found upstream of only a limited number of open reading frames, including the genes for P65 and P200, which are structurally related to HMW1 and HMW3. Promoter deletion studies demonstrated that the promoter-like region upstream of p21 was necessary for the expression of p30 and an hmw3-cat fusion in M. pneumoniae, while deletion of the promoter-like region upstream of p32 had no apparent effect. Analysis by reverse transcription-PCR confirmed transcriptional linkage of all the open reading frames in the hmw gene cluster. Taken together, these findings suggest that the genes of this locus constitute an operon expressed from overlapping transcripts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.