ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Modulation of a slowly inactivating potassium current, I(D), by metabotropic glutamate receptor activation in cultured hippocampal pyramidal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Dopamine D2 Receptor-Mediated Modulation of Rat Retinal Ganglion Cell Excitability.Neuroscience bulletin · 2020Article
- Hippocampal mGluR1-dependent long-term potentiation requires NAADP-mediated acidic store CaScience signaling · 2018Article
- Sodium and potassium conductances in principal neurons of the mouse piriform cortex: a quantitative description.The Journal of physiology · 2018Article
- The CatSper channel: a polymodal chemosensor in human sperm.The EMBO journal · 2012Article
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- Excitatory roles of protein kinase C in striatal cholinergic interneurons.Journal of neurophysiology · 2009Article
- Protracted withdrawal from alcohol and drugs of abuse impairs long-term potentiation of intrinsic excitability in the juxtacapsular bed nucleus of the stria terminalis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Dendritic D-type potassium currents inhibit the spike afterdepolarization in rat hippocampal CA1 pyramidal neurons.The Journal of physiology · 2007Article
- Presynaptic group I metabotropic glutamate receptors modulate synaptic transmission in the rat superior colliculus via 4-AP sensitive K(+) channels.British journal of pharmacology · 2003Article
- An ID-like current that is downregulated by Ca2+ modulates information coding at CA3-CA3 synapses in the rat hippocampus.The Journal of physiology · 2003Article
- Potassium currents during the action potential of hippocampal CA3 neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Activation of group I mGluRs elicits different responses in murine CA1 and CA3 pyramidal cells.The Journal of physiology · 2002Article
- Functional specificity of G alpha q and G alpha 11 in the cholinergic and glutamatergic modulation of potassium currents and excitability in hippocampal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Modulation of excitability by alpha-dendrotoxin-sensitive potassium channels in neocortical pyramidal neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Group I metabotropic glutamate receptors elicit epileptiform discharges in the hippocampus through PLCbeta1 signaling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Low-frequency Stimulation Decreases Hyperexcitability Through Adenosine A1 Receptors in the Hippocampus of Kindled Rats.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
I(D) is a slowly inactivating 4-aminopyridine (4-AP)-sensitive potassium current of hippocampal pyramidal neurons and other CNS neurons. Although I(D) exerts multifaceted influence on CNS excitability, whether I(D) is subject to modulation by neurotransmitters or neurohormones has not been clear. We report here that one prominent effect of metabotropic glutamate receptor (mGluR) activation by short (3 min) exposure to 1S, 3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) (100 microM) is suppression of I(D) by acceleration of its inactivation. I(D) was identified as a target of mGluR-mediated modulation because inactivation of a component of outward current sensitive to 100-200 microM 4-AP was accelerated by 1S,3R-ACPD, and because 4-AP occluded any further actions of 1S,3R-ACPD. Enhancement of I(D) inactivation was induced by the group I-preferring agonist RS-3, 5-dihydroxyphenylglycine (3,5-DHPG) and the group II-preferring agonist 2S,2'R,3'R)-2-(2',3'dicarboxycyclopropyl)-glycine (DCG-IV), but not by the group III-preferring agonist L(+)-2-amino-4-phosphonobutyric acid (L-AP4); it was blocked by the broadly acting mGluR antagonist S-alpha-methyl-4-carboxyphenylglycine (S-MCPG). Furthermore, inactivation of I(D) was enhanced by inclusion of GTPgammaS in the internal solution and blocked by inclusion of GDPbetaS. Metabotropic GluR-induced suppression of I(D) was manifest in three aspects of excitability previously linked to I(D) by their sensitivity to 4-AP: reduction in input conductance and enhanced excitability at voltages just positive to the resting potential, reduced delay to action potential firing during depolarizing current injections, and delayed action potential repolarization. We suggest that mGluR-induced suppression of I(D) could contribute to enhancement of hippocampal neuron excitability and synaptic connections.
Indexed as
Identifiers
10436040PMC6782886W1922134188What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.