ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Distinct functions for cotransmitters mediating motor pattern selection.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 98 citations in OpenAlex.
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- Multistable properties of human subthalamic nucleus neurons in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Substrates for Neuronal Cotransmission With Neuropeptides and Small Molecule Neurotransmitters inFrontiers in cellular neuroscience · 2018Review
- General Principles of Neuronal Co-transmission: Insights From Multiple Model Systems.Frontiers in neural circuits · 2018Review
- State-dependent sensorimotor gating in a rhythmic motor system.Journal of neurophysiology · 2017Article
- Circuit feedback increases activity level of a circuit input through interactions with intrinsic properties.Journal of neurophysiology · 2017Article
- Functional consequences of neuropeptide and small-molecule co-transmission.Nature reviews. Neuroscience · 2017Review
- Segregation of glutamatergic and cholinergic transmission at the mixed motoneuron Renshaw cell synapse.Scientific reports · 2017Article
- Complicating connectomes: Electrical coupling creates parallel pathways and degenerate circuit mechanisms.Developmental neurobiology · 2017Review
- The complexity of small circuits: the stomatogastric nervous system.Current opinion in neurobiology · 2016Review
- The Site of Spontaneous Ectopic Spike Initiation Facilitates Signal Integration in a Sensory Neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Convergent neuromodulation onto a network neuron can have divergent effects at the network level.Journal of computational neuroscience · 2016Article
- Specificity of repetition priming: the role of chemical coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Coordination of distinct but interacting rhythmic motor programs by a modulatory projection neuron using different co-transmitters in different ganglia.The Journal of experimental biology · 2013Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Motor patterns are selected from multifunctional networks by selective activation of different projection neurons, many of which contain multiple transmitters. Little is known about how any individual projection neuron uses its cotransmitters to select a motor pattern. We address this issue by using the stomatogastric ganglion (STG) of the crab Cancer borealis, which contains a neuronal network that generates multiple versions of the pyloric and gastric mill motor patterns. The functional flexibility of this network results mainly from modulatory inputs it receives from projection neurons that originate in neighboring ganglia. We demonstrated previously that the STG motor pattern selected by activation of the modulatory proctolin neuron (MPN) results from direct MPN modulation of the pyloric rhythm and indirect MPN inhibition of the gastric mill rhythm. The latter action results from MPN inhibition of projection neurons that excite the gastric mill rhythm. These projection neurons are modulatory commissural neuron 1 (MCN1) and commissural projection neuron 2 (CPN2). MPN excitation of the pyloric rhythm is mimicked by bath application of proctolin, its peptide transmitter. Here, we show that MPN uses only its small molecule transmitter, GABA, to inhibit MCN1 and CPN2 within their ganglion of origin. We also demonstrate that MPN has no proctolin-mediated influence on MCN1 or CPN2, although exogenously applied proctolin directly excites these neurons. Thus, motor pattern selection occurs during MPN activation via proctolin actions on the STG network and GABA-mediated actions on projection neurons in the commissural ganglia, demonstrating a spatial and functional segregation of cotransmitter actions.
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Identifiers
10436035PMC6782841W1583914347What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.