ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Transistor probes local potassium conductances in the adhesion region of cultured rat hippocampal neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Macrophages sense and follow physiologically relevant KCell communication and signaling : CCS · 2026Article
- Real-time encoding and compression of neuronal spikes by metal-oxide memristors.Nature communications · 2016Article
- Current-Induced Transistor Sensorics with Electrogenic Cells.Biosensors · 2016Review
- Interfacing Cultured Neurons to Microtransducers Arrays: A Review of the Neuro-Electronic Junction Models.Frontiers in neuroscience · 2016Review
- In vitro studies of neuronal networks and synaptic plasticity in invertebrates and in mammals using multielectrode arrays.Neural plasticity · 2015Review
- Overview of micro- and nano-technology tools for stem cell applications: micropatterned and microelectronic devices.Sensors (Basel, Switzerland) · 2012Review
- Functional Na+ channels in cell adhesion probed by transistor recording.Biophysical journal · 2006Article
- Cell-transistor coupling: investigation of potassium currents recorded with p- and n-channel FETs.Biophysical journal · 2005Article
- Micro Photo Detector Fabricated of Ferroelectric-Metal Heterostructure.Japanese journal of applied physics. Part 1, Regular papers & short notes · 2005Article
- Neuron-transistor coupling: interpretation of individual extracellular recorded signals.European biophysics journal : EBJ · 2005Article
- Potassium channel gating in adhesion: from an oocyte-silicon to a neuron-astrocyte adhesion contact.European biophysics journal : EBJ · 2005Article
- Imaging neuronal seal resistance on silicon chip using fluorescent voltage-sensitive dye.Biophysical journal · 2004Article
- Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adhesion interactions of neurons in a tissue may affect the ion conductance of the plasma membrane, inducing selective localization and modulation of channels. We studied the adhesion region of cultured neurons from rat hippocampus as a defined model where such effects could be observed electrophysiologically, taking advantage of extracellular recording by a transistor integrated in the substrate. We observed the K(+) current through the region of soma adhesion under voltage-clamp and compared it with the current through the whole cell. We found that the specific A-type conductance was depleted, even completely, in the region of adhesion, whereas the specific K-type conductance was enhanced up to a factor of 12. The electrophysiological approach opens a new way to investigate targeting of ion channels in the cell membrane as a function of adhesion processes.
Indexed as
Identifiers
10436034PMC6782847What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.