ArticleMolecular biology of the cell1999
Syntaxin is required for cell division.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 59 citations in OpenAlex.
- Non-Neuronal Transmitter Systems in Bacteria, Non-Nervous Eukaryotes, and Invertebrate Embryos.Biomolecules · 2022Review
- SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Polar expansion during cytokinesis.Cytoskeleton (Hoboken, N.J.) · 2012Article
- 'Life is a highway': membrane trafficking during cytokinesis.Traffic (Copenhagen, Denmark) · 2011Review
- Understanding cytokinesis failure.Advances in experimental medicine and biology · 2010Review
- TRAPPII is required for cleavage furrow ingression and localization of Rab11 in dividing male meiotic cells of Drosophila.Journal of cell science · 2009Article
- Cell Cycle-Dependent Localization of Voltage-Dependent Calcium Channels and the Mitotic Apparatus in a Neuroendocrine Cell Line(AtT-20).International journal of cell biology · 2009Article
- Two independent forms of endocytosis maintain embryonic cell surface homeostasis during early development.Developmental biology · 2008Article
- Secretory mechanisms and Ca2+ signaling in gametes: similarities to regulated neuroendocrine secretion in somatic cells and involvement in emerging pathologies.Endocrine pathology · 2007Review
- The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis.Molecular biology of the cell · 2005Article
- Actin cytoskeleton remodeling during early Drosophila furrow formation requires recycling endosomal components Nuclear-fallout and Rab11.The Journal of cell biology · 2003Article
- Targeted new membrane addition in the cleavage furrow is a late, separate event in cytokinesis.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Completion of cytokinesis in C. elegans requires a brefeldin A-sensitive membrane accumulation at the cleavage furrow apex.Current biology : CB · 2001Article
- Lava lamp, a novel peripheral golgi protein, is required for Drosophila melanogaster cellularization.The Journal of cell biology · 2000Article
- Roles for focal adhesion kinase (FAK) in blastomere abscission and vesicle trafficking during cleavage in the sea urchin embryo.Mechanisms of developmentArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We recently identified a single family member homologue of syntaxin in the sea urchin. Syntaxin is present throughout development, and in rapidly dividing cleavage stage embryos it is present on numerous vesicles at the cell cortex. We hypothesized that syntaxin mediates essential membrane fusion events during early embryogenesis, reasoning that the vesicles and/or their contents are important for development. Here we show that functional inactivation of syntaxin with either Botulinum neurotoxin C1, which specifically proteolyzes syntaxin, or antibodies against syntaxin results in an inhibition of cell division. These observations suggest that syntaxin is essential for membrane fusion events critical for cell division.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.