ReviewMolecular biology of the cell1999
Molecular interaction map of the mammalian cell cycle control and DNA repair systems.
Review in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed, 560 citations in OpenAlex.
- WayFindR: investigating feedback in biological pathways.NAR genomics and bioinformatics · 2026Article
- textToKnowledgeGraph: generation of molecular interaction knowledge graphs using large language models for exploration in Cytoscape.Bioinformatics (Oxford, England) · 2026Article
- Data-driven discovery of digital twins in biomedical research.Briefings in bioinformatics · 2026Review
- TOPAS-Tissue: A Framework for the Simulation of the Biological Response to Ionizing Radiation at the Multi-Cellular Level.International journal of molecular sciences · 2024Article
- Comprehensive molecular interaction map of TGFβ induced epithelial to mesenchymal transition in breast cancer.NPJ systems biology and applications · 2024Article
- The oscillation of mitotic kinase governs cell cycle latches in mammalian cells.Journal of cell science · 2024Article
- Article
- Protein kinase C epsilon activation regulates proliferation, migration, and epithelial to mesenchymal-like transition in rat Schwann cells.Frontiers in cellular neuroscience · 2023Article
- Pathway information extracted from 25 years of pathway figures.Genome biology · 2020Article
- The Atlas of Inflammation Resolution (AIR).Molecular aspects of medicine · 2020Review
- DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations.Acta neuropathologica communications · 2020Article
- Optimal treatment allocations in space and time for on-line control of an emerging infectious disease.Journal of the Royal Statistical Society. Series C, Applied statistics · 2018Article
- ndexr-an R package to interface with the network data exchange.Bioinformatics (Oxford, England) · 2018Article
- Multifactorial Modes of Action of Arsenic Trioxide in Cancer Cells as Analyzed by Classical and Network Pharmacology.Frontiers in pharmacology · 2018Article
- BEL Commons: an environment for exploration and analysis of networks encoded in Biological Expression Language.Database : the journal of biological databases and curation · 2018Article
- Systems medicine disease maps: community-driven comprehensive representation of disease mechanisms.NPJ systems biology and applications · 2018Article
- Secretion modification region-derived peptide blocks exosome release and mediates cell cycle arrest in breast cancer cells.Oncotarget · 2017Article
- Single-nucleus RNA-seq of differentiating human myoblasts reveals the extent of fate heterogeneity.Nucleic acids research · 2016Article
- DNA-binding protects p53 from interactions with cofactors involved in transcription-independent functions.Nucleic acids research · 2016Article
- Systems medicine in colorectal cancer: from a mathematical model toward a new type of clinical trial.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Eventually to understand the integrated function of the cell cycle regulatory network, we must organize the known interactions in the form of a diagram, map, and/or database. A diagram convention was designed capable of unambiguous representation of networks containing multiprotein complexes, protein modifications, and enzymes that are substrates of other enzymes. To facilitate linkage to a database, each molecular species is symbolically represented only once in each diagram. Molecular species can be located on the map by means of indexed grid coordinates. Each interaction is referenced to an annotation list where pertinent information and references can be found. Parts of the network are grouped into functional subsystems. The map shows how multiprotein complexes could assemble and function at gene promoter sites and at sites of DNA damage. It also portrays the richness of connections between the p53-Mdm2 subsystem and other parts of the network.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.