ArticleOncogene1999
Osteopontin induces increased invasiveness and plasminogen activator expression of human mammary epithelial cells.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
73 citing papers in PubMed, 188 citations in OpenAlex.
- Assessment of osteopontin in early breast cancer: correlative study in a randomised clinical trial.Breast cancer research : BCR · 2014Trial
- Lower osteopontin plasma levels are associated with superior outcomes in advanced non-small-cell lung cancer patients receiving platinum-based chemotherapy: SWOG Study S0003.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2008Trial
- Review
- Cigarette smoke-promoted increases in osteopontin expression attract mesenchymal stem cell recruitment and facilitate lung cancer metastasis.Journal of advanced research · 2022Article
- The Role of Extracellular Matrix Proteins in Breast Cancer.Journal of clinical medicine · 2022Review
- Kindlins as modulators of breast cancer progression.Journal of breast cancer research · 2021Article
- Mesenchymal Stromal Cells: Emerging Roles in Bone Metastasis.International journal of molecular sciences · 2018Review
- Article
- Osteopontin as a discriminating marker for pancreatic cancer and chronic pancreatitis.Cancer biomarkers : section A of Disease markers · 2016Article
- Pathogenesis of Warthin's tumors.Interventional medicine & applied science · 2016Review
- New Findings on Breast Cancer Stem Cells: A Review.Journal of breast cancer · 2015Review
- Prognostic value of osteopontin expression in breast cancer: A meta-analysis.Molecular and clinical oncology · 2015Article
- Role of osteopontin in the pathophysiology of cancer.Matrix biology : journal of the International Society for Matrix Biology · 2014Review
- Bone sialoprotein and osteopontin in bone metastasis of osteotropic cancers.Critical reviews in oncology/hematology · 2014Review
- Osteoponin promoter controlled by DNA methylation: aberrant methylation in cloned porcine genome.BioMed research international · 2014Article
- Article
- miR-21 represses Pdcd4 during cardiac valvulogenesis.Development (Cambridge, England) · 2013Article
- Osteopontin induces growth of metastatic tumors in a preclinical model of non-small lung cancer.Journal of experimental & clinical cancer research : CR · 2012Article
- Article
- Structure and function of the solid tumor niche.Frontiers in bioscience (Scholar edition) · 2012Review
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteopontin (OPN) has been associated with enhanced malignancy in breast cancer, but its functional role in this disease is poorly understood. To study the effect of OPN on cellular invasiveness, basal OPN expression was first assessed in members of a progression series of human mammary epithelial cell lines (21PT: immortalized, non-tumorigenic; 21NT: weakly tumorigenic; 21MT-1: tumorigenic, weakly metastatic; MDA-MB-435 cells: tumorigenic, highly metastatic). The two lines which expressed lowest basal levels of OPN (21PT, 21NT) were then examined for up-regulation of invasive behavior in response to exogenous or transfected (endogenous) OPN. Both 21PT and 21NT showed increased invasiveness through Matrigel when human recombinant (hr)OPN was added to the lower chamber of transwells. Both also showed a cell migration response to hrOPN. Populations of 21PT and 21NT cells stably transfected with an OPN-expression vector showed higher levels of cell invasiness than control vector transfectants. Examination of transfectants for mRNA of a number of secreted proteases showed that only urokinase-type plasminogen activator (uPA) expression was closely associated with OPN expression and cellular invasiveness. Treatment of the parental 21PT and 21NT cells with exogenous hrOPN resulted in increased uPA mRNA expression and increased urokinase activity of the conditioned media. Both increased cell migration and induction of uPA expression are thus potential mechanisms of increased invasiness of breast epithelial cells in response to OPN.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.