ArticleOncogene1999
CBP and histone deacetylase inhibition enhance the transactivation potential of the HOXB7 homeodomain-containing protein.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 60 citations in OpenAlex.
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- Tlx3 promotes glutamatergic neuronal subtype specification through direct interactions with the chromatin modifier CBP.PloS one · 2015Article
- Hox regulation of transcription: more complex(es).Developmental dynamics : an official publication of the American Association of Anatomists · 2014Review
- Protein interactions of the transcription factor Hoxa1.BMC developmental biology · 2012Article
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- HOXB13 is co-localized with androgen receptor to suppress androgen-stimulated prostate-specific antigen expression.Anatomy & cell biology · 2010Article
- Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors.Molecular and cellular biology · 2010Article
- Meis cofactors control HDAC and CBP accessibility at Hox-regulated promoters during zebrafish embryogenesis.Developmental cell · 2009Article
- Hox specificity unique roles for cofactors and collaborators.Current topics in developmental biology · 2009Review
- HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes.Molecular and cellular biology · 2007Article
- A genomic approach to the identification and characterization of HOXA13 functional binding elements.Nucleic acids research · 2005Article
- Role of homeobox genes in normal mammary gland development and breast tumorigenesis.Journal of mammary gland biology and neoplasia · 2003Review
- The HOX homeodomain proteins block CBP histone acetyltransferase activity.Molecular and cellular biology · 2001Article
- Article
- Cell signaling switches HOX-PBX complexes from repressors to activators of transcription mediated by histone deacetylases and histone acetyltransferases.Molecular and cellular biology · 2000Article
- Article
- Regulation of interleukin-6 gene expression by pro-inflammatory cytokines in a colon cancer cell line.The Biochemical journal · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Homeodomain-containing proteins are transcription factors regulating the coordinated expression of multiple target genes involved in development, differentiation and cellular transformation. In this study, we demonstrated that HOXB7, one member of this family, behaved as a transactivator in breast cancer cells. Deletion of either the HOXB7 N-terminal domain or the C-terminal acidic tail abolished this transcriptional effect, suggesting a combination of distinct functional transactivating domains. HOXB7 physically interacted both in vitro and in vivo with the coactivator CREB-binding protein (CBP). This interaction led to an enhanced transactivating potential and required the N-terminal of HOXB7 as well as two domains located at the C-terminal part of CBP. Moreover, trichostatin A, a deacetylase inhibitor, strongly enhanced the transcriptional properties of HOXB7. Our data therefore indicate that HOX proteins can directly interact with CBP and that acetylation/deacetylation may regulate their transcriptional properties.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.