ArticleOncogene1999
Allelic loss mapping and physical delineation of a region harboring a putative thymic lymphoma suppressor gene on mouse chromosome 12.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- Mouse models for radiation-induced cancers.Mutagenesis · 2016Review
- Mouse models for efficacy testing of agents against radiation carcinogenesis—a literature review.International journal of environmental research and public health · 2012Review
- Role of the transcription factor Bcl11b in development and lymphomagenesis.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2012Review
- Increased expression of bcl11b leads to chemoresistance accompanied by G1 accumulation.PloS one · 2010Article
- Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages.Oncogene · 2007Article
- Multi-step lymphomagenesis deduced from DNA changes in thymic lymphomas and atrophic thymuses at various times after gamma-irradiation.Oncogene · 2007Article
- Radiation carcinogenesis in mouse thymic lymphomas.Cancer science · 2006Review
- Allelic losses in mouse skin tumors induced by gamma-irradiation of p53 heterozygotes.Japanese journal of cancer research : Gann · 2002Article
- Article
- Loss of heterozygosity at the Ink4a/Arf locus facilitates Abelson virus transformation of pre-B cells.Journal of virology · 2000Article
- Homozygous deletions and point mutations of the Ikaros gene in gamma-ray-induced mouse thymic lymphomas.Oncogene · 1999Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Our previous allelic loss analysis of gamma-ray induced thymic lymphomas in F1 hybrid and backcross mice between BALB/c and MSM strains mapped the Tlsr4 region exhibiting a high frequency of allelic loss (62%) to a 2.9 cM interval between the markers D12Mit53 and D12Mit279 on mouse chromosome 12. To narrow further the interval harboring a putative tumor suppressor gene, a high-density scan has been carried out for informative 361 thymic lymphomas. Construction of a physical map of Tlsr4 with 3 YAC and 15 BAC clones and isolation of YAC- and BAC-derived polymorphic probes lead to fine allelic loss mapping. Three successive polymorphic sites within one BAC exhibit the retention of both alleles in seven, one and four lymphomas, suggesting that a common region of allelic loss for Tlsr4 exists within the BAC region. Pulsed-field gel electrophoresis of NotI digests of this and other clones determines that the commonly lost region is a 35 kb interval with a NotI site. NotI sites are frequently associated with coding regions, and our preliminary sequencing has identified ESTs in the region. Thus, the present study facilitates the identification of genes in the Tlsr4 region that would lead to isolation of a novel tumor suppressor gene.
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