ArticleThe American journal of pathology1999
Differential susceptibility to hepatic inflammation and proliferation in AXB recombinant inbred mice chronically infected with Helicobacter hepaticus.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 74 citations in OpenAlex.
- Extragastric manifestations of Helicobacter pylori infection: Possible role of bacterium in liver and pancreas diseases.World journal of hepatology · 2015Review
- Contribution of Helicobacter hepaticus cytolethal distending toxin subunits to human epithelial cell cycle arrest and apoptotic death in vitro.Helicobacter · 2013Article
- Effects of human and porcine bile on the proteome of Helicobacter hepaticus.Proteome science · 2012Article
- Quantitative trait loci in a bacterially induced model of inflammatory bowel disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer.Mucosal immunology · 2011Review
- Experimental Helicobacter marmotae infection in A/J mice causes enterohepatic disease.Journal of medical microbiology · 2010Article
- Persistent infection of rhesus monkeys with 'Helicobacter macacae' and its isolation from an animal with intestinal adenocarcinoma.Journal of medical microbiology · 2010Article
- Cytolethal distending toxin promotes Helicobacter cinaedi-associated typhlocolitis in interleukin-10-deficient mice.Infection and immunity · 2009Article
- Marked liver tumorigenesis by Helicobacter hepaticus requires perinatal exposure.Environmental health perspectives · 2008Article
- Helicobacter hepaticus urease is not required for intestinal colonization but promotes hepatic inflammation in male A/JCr mice.Microbial pathogenesis · 2008Article
- Article
- Enterohepatic Helicobacter species are prevalent in mice from commercial and academic institutions in Asia, Europe, and North America.Journal of clinical microbiology · 2007Article
- Rapid onset of ulcerative typhlocolitis in B6.129P2-IL10tm1Cgn (IL-10-/-) mice infected with Helicobacter trogontum is associated with decreased colonization by altered Schaedler's flora.Infection and immunity · 2006Article
- Cytolethal distending toxin is essential for Helicobacter hepaticus colonization in outbred Swiss Webster mice.Infection and immunity · 2005Article
- Prevalence of Helicobacter pullorum among patients with gastrointestinal disease and clinically healthy persons.Journal of clinical microbiology · 2005Article
- Gastroenteritis in NF-kappaB-deficient mice is produced with wild-type Camplyobacter jejuni but not with C. jejuni lacking cytolethal distending toxin despite persistent colonization with both strains.Infection and immunity · 2004Article
- Helicobacter-induced chronic active lymphoid aggregates have characteristics of tertiary lymphoid tissue.Infection and immunity · 2003Article
- CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice.The American journal of pathology · 2003Article
- Helicobacter marmotae sp. nov. isolated from livers of woodchucks and intestines of cats.Journal of clinical microbiology · 2002Article
- Simple epithelium keratins 8 and 18 provide resistance to Fas-mediated apoptosis. The protection occurs through a receptor-targeting modulation.The Journal of cell biology · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Helicobacter hepaticus is a naturally occurring pathogen of mice and has been used to develop models of chronic hepatitis, liver cancer, and, more recently, inflammatory bowel disease, in selected mouse strains. A/JCr mice are particularly susceptible to H. hepaticus-induced hepatitis and subsequent development of liver neoplasms, whereas C57BL/6 mice are resistant. In this study, we inoculated nine AXB recombinant inbred (RI) mouse strains, derived from A/J and C57BL/6 mice, with H. hepaticus to determine the genetic basis of resistance to Helicobacter-induced liver disease. Mice were surveyed 14 months after inoculation by culture and PCR for H. hepaticus colonization of the liver and cecum, and microscopic morphometric evaluations of the liver were performed to quantify and correlate the severity of inflammation, apoptosis, and proliferation. Analysis of variance of hepatic inflammation demonstrated significant variation among the RI strains (P < 0.0001), and the strain distribution pattern suggested a multigenic basis of disease resistance. Quantitative trait analysis using linear regression suggested possible linkage to loci on mouse chromosome 19. Hepatocellular and biliary epithelial apoptosis and proliferation indices, including proliferation of oval cells, were markedly increased and correlated with severity of inflammation. Prevalence of hepatic neoplasia was also increased in susceptible RI strains. These findings demonstrate a genetic basis for susceptibility to Helicobacter-induced disease and provide insight into its pathogenesis.
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