Evidence map›Paper›PMID 10433943›Full record

ArticleThe American journal of pathology1999

Changing roles of cadherins and catenins during progression of squamous intraepithelial lesions in the uterine cervix.

C J de Boer, E van Dorst, H van Krieken, C M Jansen-van Rhijn, S O Warnaar, G J Fleuren, S V Litvinov

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 87 citations in OpenAlex.

  1. Trial
  2. Beyond the Barrier: Epithelial Cells as Immune Sentinels in the Female Genital Tract.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
  3. Article
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  5. Article
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  11. Article
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  15. Review
  16. Article
  17. Article
  18. Article
  19. Cervical cancer screening.Current oncology reports · 2004
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

C J de BoerDepartment of Pathology, Leiden University Medical Center, Leiden Academic Hospital Utrecht, Utrecht, The Netherlands.
E van Dorst
H van Krieken
C M Jansen-van Rhijn
S O Warnaar
G J Fleuren
S V Litvinov
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Uterine cervix represents a convenient model for the study of the gradual transformation of normal squamous epithelium via low- to high-grade squamous intraepithelial lesions (SILs). Because SIL, on the basis of the cytokeratins expressed, are thought to originate from the reserve cells, we analyzed whether SILs also show a reserve cell phenotype with respect to intercellular interactions. The changes in expression and subcellular localization of the components of the adherens junction and desmosomal complexes were investigated in normal, metaplastic, and premalignant cervical epithelium, as well as in cell cultures derived from these tissues. The results suggest that 1) during progression of SILs, E-cadherin is suppressed, with its role in cell-cell connections diminishing; 2) P-cadherin, in contrast, becomes the predominant cadherin in high-grade SILs; 3) the level of cellular alpha-catenin is dramatically decreased in high-grade SILs; 4) the level of beta-catenin is decreased during progression of SILs, with plakoglobin suggestively becoming the predominant catenin mediating connection of cadherins to the cytoskeleton; 5) the assembly of desmosomes is affected during progression of SILs and is accompanied by a dramatically decreased expression for desmogleins and desmoplakins (I, II); and 6) expression of differentiation markers (involucrin, CK13) in high-grade SILs seems to be controlled by P-cadherin as opposed to E-cadherin in the normal tissue counterpart. We conclude that during development of cervical lesions substantial (both quantitative and qualitative) changes occur in cell-cell junctions, making the interactions of cells in lesions dissimilar from those of reserve cells, basal cells, or cells of immature squamous metaplasia, despite existing morphological similarity between all of these cell types and cells of high-grade lesions.

Indexed as

Trans-Activatorsalpha Cateninbeta CateninBiomarkersCadherinsCell Adhesion MoleculesCells, CulturedCytoskeletal ProteinsDesmogleinsDesmoplakinsDesmosomesDisease ProgressionFemaleFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine Kinasesgamma Cateninalpha Cateninbeta CateninBiomarkersCadherinsCell Adhesion MoleculesCTNNA1 protein, humanCTNNB1 protein, humanCytoskeletal ProteinsDesmogleinsDesmoplakinsFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine Kinasesgamma CateninProtein-Tyrosine KinasesPTK2 protein, humanTrans-Activators

Identifiers

PMID10433943
PMCPMC1866872
OpenAlexW2016067272

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.