ArticleBritish journal of pharmacology1999
Molecular and pharmacological evidence for MT1 melatonin receptor subtype in the tail artery of juvenile Wistar rats.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 66 citations in OpenAlex.
- Orchestration of PKC-Mediated Inhibition and Calcium Release-Mediated Activation of BK Currents in Rat Vascular Smooth Muscle Cells by Melatonin Confers a BK-Channel-Dependent Restraint on Melatonin-Induced Vasocontraction.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- Dark-phase melatonin administration does not reduce blood pressure but induces changes in parameters related to the control of the cardiovascular system in spontaneously hypertensive rats.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Rs4862705 in the melatonin receptor 1A gene is associated with renal function decline in type 1 diabetes individuals.Frontiers in endocrinology · 2024Article
- Circadian Rhythms Disrupted by Light at Night and Mistimed Food Intake Alter Hormonal Rhythms and Metabolism.International journal of molecular sciences · 2023Review
- Role of Melatonin in Plant Tolerance to Soil Stressors: Salinity, pH and Heavy Metals.Molecules (Basel, Switzerland) · 2020Review
- The Mystery behind the Pineal Gland: Melatonin Affects the Metabolism of Cholesterol.Oxidative medicine and cellular longevity · 2019Review
- Melatonin in Edible and Non-Edible Plants.Turkish journal of pharmaceutical sciences · 2017Review
- The Concise Guide to PHARMACOLOGY 2013/14: G protein-coupled receptors.British journal of pharmacology · 2013Article
- Characterization of signaling pathways coupled to melatonin receptors in gastrointestinal smooth muscle.Regulatory peptides · 2013Article
- The presence and localization of melatonin receptors in the rat aorta.Cellular and molecular neurobiology · 2011Article
- Melatonin inhibits tachykinin NK₂ receptor-triggered 5-HT release from guinea pig isolated colonic mucosa.British journal of pharmacology · 2011Article
- International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, classification, and pharmacology of G protein-coupled melatonin receptors.Pharmacological reviews · 2010Article
- Article
- GPR50 is the mammalian ortholog of Mel1c: evidence of rapid evolution in mammals.BMC evolutionary biology · 2008Article
- Targeted disruption of the mouse Mel(1b) melatonin receptor.Molecular and cellular biology · 2003Article
- An endogenous 5-HT(7) receptor mediates pigment granule dispersion in Xenopus laevis melanophores.British journal of pharmacology · 2001Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. In this study reverse transcriptase-polymerase chain reaction (RT-PCR) has been used to identify mt1 and MT2 receptor mRNA expression in the rat tail artery. The contributions of both receptors to the functional response to melatonin were examined with the putative selective MT2 receptor antagonists, 4-phenyl-2-propionamidotetraline (4-P-PDOT) and 2-benzyl-N-pentanoyltryptamine. In addition, the action of melatonin on the second messenger cyclic AMP was investigated. 2. Using RT-PCR, mt1 receptor mRNA was detected in the tail artery from seven rats. In contrast MT2 receptor mRNA was not detected even after nested PCR. 3. At low concentrations of the MT2 selective ligands, neither 10 nM 4-P-PDOT (pEC50=8.70+/-0.31 (control) vs 8.73+/-0.16, n=6) nor 60 nM 2-benzyl-NV-pentanoyltryptamine (pEC50= 8.53+/-0.20 (control) vs 8.83+/-0.38, n = 6) significantly altered the potency of melatonin in the rat tail artery. 4. At concentrations non-selective for mt1 and MT2 receptors. 4-P-PDOT (3 microM) and 2-benzyl-N-pentanoyltryptamine (5 microM) caused a significant rightward displacement of the vasoconstrictor effect of melatonin. In the case of 4-P-PDOT, the estimated pKB (6.17+/-0.16, n=8) is similar to the binding affinity for mt1 receptor. 5. Pre-incubation with 1 microM melatonin did not affect the conversion of [3H]-adenine to [3H]-cyclic AMP under basal condition (0.95+/-0.19% conversion (control) vs 0.92+/-0.19%, n=4) or following exposure to 30 microM forskolin (5.20+/-1.30% conversion (control) vs 5.35+/-0.90%, n=4). 6. Based on the above findings, we conclude that melatonin receptor on the tail artery belongs to the MT1 receptor subtype, and that this receptor is probably independent of the adenylyl cyclase pathway.
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