ArticleBritish journal of pharmacology1999
Characterization of beta-adrenoceptor mediated smooth muscle relaxation and the detection of mRNA for beta1-, beta2- and beta3-adrenoceptors in rat ileum.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 71 citations in OpenAlex.
- Attenuation of intestinal peristalsis with age is attributed to decreased sensitivity of receptors in the enteric nervous system.Cell and tissue research · 2025Article
- Beta-Blockers and Their Current Role in Maternal and Neonatal Health: A Narrative Review of the Literature.Cureus · 2023Review
- Effects of dibenzylbutyrolactone lignans arctigenin and trachelogenin on the motility of isolated rat ileum.Toxicology reports · 2022Article
- A link between gastrointestinal disorders and migraine: Insights into the gut-brain connection.Headache · 2021Review
- Light-Mediated Inhibition of Colonic Smooth Muscle Constriction and Colonic MotilityFrontiers in physiology · 2021Article
- βBritish journal of pharmacology · 2019Review
- Safety and Efficacy ofEvidence-based complementary and alternative medicine : eCAM · 2018Article
- Antispasmodic and bronchorelaxant activities of Salsola imbricata are mediated through dual CaPharmaceutical biology · 2017Article
- Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle βScientific reports · 2017Article
- Spasmolytic and Anti-Spasmodic Action of Trachyspermum ammi Essence on Rat's Ileum Contraction.North American journal of medical sciences · 2014Article
- Rat β₃-adrenoceptor protein expression: antibody validation and distribution in rat gastrointestinal and urogenital tissues.Naunyn-Schmiedeberg's archives of pharmacology · 2014Article
- Esophagus motility in overt hypothyroidism.Journal of endocrinological investigation · 2014Article
- The Relaxant Effect of Seed's Essential Oil and Oleo-Gum-Resin of Ferula Assa-Foetida on Isolated Rat's Ileum.Annals of medical and health sciences research · 2014Article
- Relaxant effect of Humulus lupulus extracts on isotonic rat's ileum contractions.Avicenna journal of phytomedicine · 2014Article
- CL316,243, a selective β3-adrenoceptor agonist, activates protein translation through mTOR/p70S6K signaling pathway in rat skeletal muscle cells.Pflugers Archiv : European journal of physiology · 2013Article
- β(2)-Adrenoceptors increase translocation of GLUT4 via GPCR kinase sites in the receptor C-terminal tail.British journal of pharmacology · 2012Article
- Role of β-adrenoceptors in glucose uptake in astrocytes using β-adrenoceptor knockout mice.British journal of pharmacology · 2011Article
- β(3) Receptors: Role in Cardiometabolic Disorders.Therapeutic advances in endocrinology and metabolism · 2011Article
- Tissue functions mediated by beta(3)-adrenoceptors-findings and challenges.Naunyn-Schmiedeberg's archives of pharmacology · 2010Article
- Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma.Phytotherapy research : PTR · 2010Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Functional and molecular approaches were used to characterize the beta-AR subtypes mediating relaxation of rat ileal smooth muscle. 2. In functional studies, (-)-isoprenaline relaxation was unchanged by CGP20712A (beta1-AR antagonist) or ICI118551 (beta2-AR antagonist) but shifted by propranolol (pKB=6.69). (+/-)-Cyanopindolol, CGP12177 and ICID7114 did not cause relaxation but antagonized (-)-isoprenaline relaxation. 3. BRL37344 (beta3-AR agonist) caused biphasic relaxation. The high affinity component was shifted with low affinity by propranolol, (+/-)-cyanopindolol, tertatolol and alprenolol. CL316243 (beta3-AR agonist) relaxation was unaffected by CGP20712A or ICI118551 but blocked by SR58894A (beta3-AR antagonist; pA2 = 7.80). Enhanced relaxation after exposure to forskolin and pertussis toxin showed that beta3-AR relaxation can be altered by manipulation of components of the adenylate cyclase signalling pathway. 4. The beta-AR agonist RO363 relaxed the ileum (pEC50=6.18) and was blocked by CGP20712A. Relaxation by the beta2-AR agonist zinterol (pEC50=5.71) was blocked by SR58894A but not by ICI118551. 5. In rat ileum, beta1-, beta2- and beta3-AR mRNA was detected. Comparison of tissues showed that beta3-AR mRNA expression was greatest in WAT>colon=ileum >cerebral cortex>soleus; beta1-AR mRNA was most abundant in cerebral cortex > WAT > ileum = colon > soleus; beta2-AR mRNA was expressed in soleus > WAT > ileum = colon > cerebral cortex. 6. These results show that beta3-ARs are the predominant beta-AR subtype mediating rat ileal relaxation while beta1-ARs may produce a small relaxation. The beta2-AR agonist zinterol produces relaxation through beta3-ARs and there was no evidence for the involvement of beta2-ARs in relaxation despite the detection of beta2-AR mRNA.
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