ArticleBritish journal of pharmacology1999
Induction of prostanoid, nitric oxide, and cytokine formation in rat bone marrow derived macrophages by activin A.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 91 citations in OpenAlex.
- Gastrointestinal pharmacology activins in liver health and disease.Biochemical pharmacology · 2023Review
- Deletion of activin A in mesenchymal but not myeloid cells ameliorates disease severity in experimental arthritis.Annals of the rheumatic diseases · 2022Article
- Inflammatory priming enhances mesenchymal stromal cell secretome potential as a clinical product for regenerative medicine approaches through secreted factors and EV-miRNAs: the example of joint disease.Stem cell research & therapy · 2020Article
- Androgen-Influenced Polarization of Activin A-Producing Macrophages Accompanies Post-pyelonephritic Renal Scarring.Frontiers in immunology · 2020Article
- The activin-follistatin anti-inflammatory cycle is deregulated in synovial fibroblasts.Arthritis research & therapy · 2019Article
- The Activin Social Network: Activin, Inhibin, and Follistatin in Breast Development and Cancer.Endocrinology · 2019Review
- Activin A increases phagocytosis of Escherichia coli K1 by primary murine microglial cells activated by toll-like receptor agonists.Journal of neuroinflammation · 2018Article
- Activin A inhibition attenuates sympathetic neural remodeling following myocardial infarction in rats.Molecular medicine reports · 2018Article
- Transforming Growth Factor β Superfamily Signaling in Development of Colorectal Cancer.Gastroenterology · 2017Review
- Transcriptional changes in mesenteric and subcutaneous adipose tissue from Holstein cows in response to plane of dietary energy.Journal of animal science and biotechnology · 2017Article
- Human fallopian tube proteome shows high coverage of mesenchymal stem cells associated proteins.Bioscience reports · 2016Article
- Article
- Inhibins tune the thymocyte selection process by regulating thymic stromal cell differentiation.Journal of immunology research · 2015Article
- Role of activins in embryo implantation and diagnosis of ectopic pregnancy: a review.Reproductive biology and endocrinology : RB&E · 2014Article
- Activin A: a potential therapeutic target for characterizing and stopping joint pain early in rheumatoid arthritis patients.Inflammation · 2014Article
- Serum activin A and B levels predict outcome in patients with acute respiratory failure: a prospective cohort study.Critical care (London, England) · 2013Article
- Activin, neutrophils, and inflammation: just coincidence?Seminars in immunopathology · 2013Review
- DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions.Cancer prevention research (Philadelphia, Pa.) · 2010Article
- Upregulation of activin signaling in experimental colitis.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Activin A induces dendritic cell migration through the polarized release of CXC chemokine ligands 12 and 14.Blood · 2009Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. In this study we describe that activin A, a transforming growth factor (TGF) beta-like polypeptide affects the expression of inflammatory response genes and their products. 2. In rat bone marrow derived macrophages 15 nM activin A caused the stimulation of prostaglandin (PG) E2 and thromboxane (TX) A2 formation, production of nitrite as a marker for nitric oxide (NO) and the release of the cytokines tumour necrosis factor (TNF) alpha and interleukin (IL) -1beta. As shown by mRNA analysis induction of cyclo-oxygenase-2 and inducible nitric oxide synthase by activin A gave rise to the enhanced release of prostanoids and NO. 3. Costimulation of bone marrow derived macrophages with 15 nM activin A and 100 nM 12-O-tetradecanoyl-phorbol 13-acetate (TPA) potentiated the synthesis of prostanoids in a synergistic manner. With respect to NO formation the effect of activin A and TPA was additive. 4. In contrast to the nitrite production activin A induced PGE2 synthesis was susceptible to tyrosine kinase inhibition by genistein and tyrphostin 46 (IC50 was 10 and 20 microM, respectively). This observed inhibition was caused by the selective suppression of activin A induced cyclo-oxygenase-2 mRNA expression. Further, the release of TNFalpha in the presence of activin A was potentiated by tyrosine kinase inhibition. 5. In summary, we report that activin A exerts proinflammatory activity which results in the formation of prostanoids, NO and cytokines in rat bone marrow derived macrophages. Tyrosine kinase dependent and independent signalling pathways are involved leading to the increased synthesis of these metabolites. Based upon these results, we speculate that activin A may be considered as a possible component of inflammatory processes affecting at least the haematopoietic system.
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