ArticleThe Journal of physiology1999
Unitary nature of regenerative potentials recorded from circular smooth muscle of guinea-pig antrum.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- Pacemaking in the lymphatic system.The Journal of physiology · 2026Review
- Functional roles of interstitial cells of Cajal in the GI tract of rats.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- Calcium transients in intramuscular interstitial cells of Cajal of the murine gastric fundus and their regulation by neuroeffector transmission.The Journal of physiology · 2022Article
- Insights on gastrointestinal motility through the use of optogenetic sensors and actuators.The Journal of physiology · 2022Review
- CaThe Journal of physiology · 2022Article
- NaFrontiers in physiology · 2020Article
- CaThe Journal of physiology · 2019Article
- The cells and conductance mediating cholinergic neurotransmission in the murine proximal stomach.The Journal of physiology · 2018Article
- Electrical stimulation of gut motility guided by an in silico model.Journal of neural engineering · 2017Article
- The Potential for Gut Organoid Derived Interstitial Cells of Cajal in Replacement Therapy.International journal of molecular sciences · 2017Review
- Na+-K+-Cl- cotransporter (NKCC) maintains the chloride gradient to sustain pacemaker activity in interstitial cells of Cajal.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Spontaneous Ca(2+) transients in interstitial cells of Cajal located within the deep muscular plexus of the murine small intestine.The Journal of physiology · 2016Article
- Spatial Noise in Coupling Strength and Natural Frequency within a Pacemaker Network; Consequences for Development of Intestinal Motor Patterns According to a Weakly Coupled Phase Oscillator Model.Frontiers in neuroscience · 2016Article
- The significance of interstitial cells in neurogastroenterology.Journal of neurogastroenterology and motility · 2014Article
- Mitochondrial calcium handling within the interstitial cells of Cajal.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Purinergic neuromuscular transmission is absent in the colon of P2Y(1) knocked out mice.The Journal of physiology · 2012Article
- Electrical slow waves in the mouse oviduct are dependent upon a calcium activated chloride conductance encoded by Tmem16a.Biology of reproduction · 2012Article
- Electrical slow waves in the mouse oviduct are dependent on extracellular and intracellular calcium sources.American journal of physiology. Cell physiology · 2011Article
- Biophysically based modeling of the interstitial cells of cajal: current status and future perspectives.Frontiers in physiology · 2011Article
- Interstitial cells of Cajal, the Maestro in health and disease.World journal of gastroenterology · 2010Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. When short segments of single bundles of circular muscle of guinea-pig antrum were isolated and impaled with two microelectrodes, the membrane potential recordings displayed an ongoing discharge of noise. 2. Treating the preparations with acetoxymethyl ester form of BAPTA (BAPTA AM) reduced the membrane noise and revealed discrete depolarizing unitary potentials. The spectral densities determined from control preparations and ones loaded with BAPTA had similar shapes but those from control preparations had higher amplitudes, suggesting that membrane noise results from a high frequency discharge of unitary potentials. 3. Depolarization of isolated segments of antrum initiated regenerative responses. These responses, along with membrane noise and unitary potentials, were inhibited by a low concentration of caffeine (1 mM). 4. Loading the preparations with BAPTA decreased the amplitudes of regenerative responses. Depolarization was now seen to increase the frequency and mean amplitude of unitary potentials over a time course similar to that of a regenerative potential. 5. Noise spectra determined during periods of rest, during regenerative potentials triggered by direct depolarization and during slow waves, recorded from preparations containing interstitial cells of Cajal (ICC), had very similar shapes but different amplitudes. 6. The observations suggest that a regenerative potential, the secondary component of a slow wave, is made up of a cluster of several discrete unitary potentials rather than from the activation of voltage-dependent ion channels.
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