ArticleThe Journal of physiology1999
Nitric oxide synthase inhibitors reduce sarcomere addition in rat skeletal muscle.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Effect of perindopril on physical function in elderly people with functional impairment: a randomized controlled trial.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2007Trial
- Age-related differences in the loss and recovery of serial sarcomere number following disuse atrophy in rats.Skeletal muscle · 2024Article
- Influence of weighted downhill running training on serial sarcomere number and work loop performance in the rat soleus.Biology open · 2022Article
- Angiotensin-Converting Enzyme Inhibitor Use and Incident Frailty: A Longitudinal Cohort Study.Drugs & aging · 2019Article
- Relation of nNOS isoforms to mitochondrial density and PGC-1alpha expression in striated muscles of mice.Nitric oxide : biology and chemistry · 2018Article
- Exercise-induced skeletal muscle remodeling and metabolic adaptation: redox signaling and role of autophagy.Antioxidants & redox signaling · 2014Review
- Modulation of stretch-induced myocyte remodeling and gene expression by nitric oxide: a novel role for lipoma preferred partner in myofibrillogenesis.American journal of physiology. Heart and circulatory physiology · 2013Article
- The muscle fiber type-fiber size paradox: hypertrophy or oxidative metabolism?European journal of applied physiology · 2010Review
- Exercise training modulates the nitric oxide synthase profile in skeletal muscle from old rats.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Article
- Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise.European journal of applied physiology · 2008Article
- Modulation of GH/IGF-1 axis: potential strategies to counteract sarcopenia in older adults.Mechanisms of ageing and development · 2008Review
- Mechanotransduction in skeletal muscle.Frontiers in bioscience : a journal and virtual library · 2007Review
- Arginine supplementation induces myoblast fusion via augmentation of nitric oxide production.Journal of muscle research and cell motility · 2006Article
- Reactive oxygen species and redox-regulation of skeletal muscle adaptations to exercise.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- Signaling from novel splice variants of hormone receptors in cancer.International journal of gastrointestinal cancer · 2002Review
- Ace inhibitors as a therapy for sarcopenia - evidence and possible mechanisms.The journal of nutrition, health & agingReview
- Effect of NO on satellite cell proliferation during functional unloading and muscle stretching.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
1. Mechanical stimuli are thought to modulate the number of sarcomeres in series (sarcomere number) in skeletal muscle fibres. However, the mechanisms by which muscle cells transduce mechanical signals into serial sarcomere addition have not been explored. In this study, we test the hypothesis that nitric oxide positively modulates sarcomere addition. 2. The soleus muscle was cast-immobilized in a shortened position in 3-week-old female Wistar rats. After 4 weeks, the casts were removed, creating a period of rapid sarcomere addition. During the remobilization period, nitric oxide synthase (NOS) inhibitors or substrate were administered. 3. Rats treated with the non-isoform-specific NOS inhibitor L-nitro-arginine methyl ester during 3 weeks of remobilization had smaller soleus sarcomere numbers than control rats. Rats treated with 1-(2-trifluoromethyl-phenyl)-imidazole, which has greater specificity for the neuronal isoform than for the endothelial isoform of NOS, also had smaller soleus sarcomere numbers than control rats. These results suggest that inhibition of the neuronal isoform of NOS reduces sarcomere addition during remobilization. 4. Rats treated with L-arginine, the substrate for NOS, during 1 week of remobilization had soleus sarcomere numbers for the immobilized-remobilized muscle which were closer to that for the contralateral, non-immobilized muscle than did rats that were not treated with L-arginine. 5. These results support the hypothesis that nitric oxide derived from the neuronal isoform of NOS positively modulates sarcomere addition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.