ArticleThe Journal of physiology1999
The role of calcium stores in fatigue of isolated single muscle fibres from the cane toad.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 65 citations in OpenAlex.
- Skeletal Muscle Fatigue in Rats Is More Consistently Related to Increased Inorganic Phosphate Concentration Than Acidosis.Acta physiologica (Oxford, England) · 2025Article
- Molecular Basis for Exercise-Induced Fatigue: The Importance of Strictly Controlled Cellular CaCold Spring Harbor perspectives in medicine · 2018Review
- Article
- Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice.Nature communications · 2013Article
- Evidence for a Non-Genomic Action of Testosterone in Skeletal Muscle Which may Improve Athletic Performance: Implications for the Female Athlete.Journal of sports science & medicine · 2012Review
- Quadriceps low-frequency fatigue and muscle pain are contraction-type-dependent.Muscle & nerve · 2010Article
- Role of TRPC1 channel in skeletal muscle function.American journal of physiology. Cell physiology · 2010Article
- Electrically silent divalent cation entries in resting and active voltage-controlled muscle fibers.Biophysical journal · 2009Article
- Alterations in calcium homeostasis reduce membrane excitability in amphibian skeletal muscle.Pflugers Archiv : European journal of physiology · 2006Article
- Functional role of store-operated and stretch-activated channels in murine adult skeletal muscle fibres.The Journal of physiology · 2006Article
- The elusive role of store depletion in the control of intracellular calcium release.Journal of muscle research and cell motility · 2006Review
- Multiple sprint work : physiological responses, mechanisms of fatigue and the influence of aerobic fitness.Sports medicine (Auckland, N.Z.) · 2005Review
- Role of phosphate and calcium stores in muscle fatigue.The Journal of physiology · 2001Review
- Phosphate ion channels in sarcoplasmic reticulum of rabbit skeletal muscle.The Journal of physiology · 2001Article
- The use of the indicator fluo-5N to measure sarcoplasmic reticulum calcium in single muscle fibres of the cane toad.The Journal of physiology · 2001Article
- Inhibition of creatine kinase reduces the rate of fatigue-induced decrease in tetanic [Ca(2+)](i) in mouse skeletal muscle.The Journal of physiology · 2001Article
- Intracellular calcium during fatigue of cane toad skeletal muscle in the absence of glucose.Journal of muscle research and cell motility · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Intracellular calcium ([Ca2+]i) and tension were measured from single muscle fibres dissected from the cane toad (Bufo marinus). The amount of Ca2+ which could be released from the sarcoplasmic reticulum (SR) was estimated by brief (approximately 20 s) exposures to 4-chloro-m-cresol (4-CmC) or caffeine. 2. Muscle fatigue was produced by repeated tetani at 4 s or shorter intervals and continued until tension had fallen to 50% of the control. The intracellular free calcium concentration during a tetanus (tetanic [Ca2+]i) first increased and then steadily declined to 43+/-2% of control by the time tension had fallen to 50%. Over the period of fatigue the rapidly releasable Ca2+ from the SR fell to 46+/-6% of control. Tension and tetanic [Ca2+]i recovered to 93+/-3% and 100+/-4% of the control values after 20 min of rest. Over the same period rapidly releasable SR Ca2+ recovered to 98+/-12%. 3. When a similar number of tetani (200) were repeated at longer intervals (10 s), fibres showed only a small reduction in tension (to 85+/-1%) and tetanic [Ca2+]i did not change significantly. Under these conditions the rapidly releasable SR Ca2+ did not change significantly. 4. The recovery of rapidly releasable SR Ca2+ after fatigue was unaffected by removal of extracellular calcium but did not occur when oxidative phosphorylation was inhibited with cyanide. 5. These results suggest that an important cause of the decline of tetanic [Ca2+]i during fatigue is an equivalent decline in the amount of rapidly releasable SR Ca2+. The results show that the decline of rapidly releasable SR Ca2+ is related to a metabolic consequence of fatigue and are consistent with the hypothesis that Ca2+ precipitates with phosphate in the SR during fatigue.
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