ArticleThe Journal of physiology1999
Somatic amplification of distally generated subthreshold EPSPs in rat hippocampal pyramidal neurones.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed, 70 citations in OpenAlex.
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- Dendritic synaptic integration modes under in vivo-like states.Biophysical journal · 2025Article
- Dendrite-Specific Amplification of Weak Synaptic Input during Network Activity In Vivo.Cell reports · 2018Article
- Morphological diversity and connectivity of hippocampal interneurons.Cell and tissue research · 2018Review
- Non-Decaying postsynaptics potentials and delayed spikes in hippocampal pyramidal neurons generated by a zero slope conductance created by the persistent NaChannels (Austin, Tex.) · 2018Article
- A Negative Slope Conductance of the Persistent Sodium Current Prolongs Subthreshold Depolarizations.Biophysical journal · 2017Article
- The role of negative conductances in neuronal subthreshold properties and synaptic integration.Biophysical reviews · 2017Review
- Differential Regulation of NMDA Receptor-Mediated Transmission by SK Channels Underlies Dorsal-Ventral Differences in Dynamics of Schaffer Collateral Synaptic Function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Downregulation of Spermine Augments Dendritic Persistent Sodium Currents and Synaptic Integration after Status Epilepticus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Activation of Ih and TTX-sensitive sodium current at subthreshold voltages during CA1 pyramidal neuron firing.Journal of neurophysiology · 2015Article
- Active dendrites mediate stratified gamma-range coincidence detection in hippocampal model neurons.The Journal of physiology · 2015Article
- Recurrent synapses and circuits in the CA3 region of the hippocampus: an associative network.Frontiers in cellular neuroscience · 2014Review
- In vivo voltage-dependent influences on summation of synaptic potentials in neurons of the lateral nucleus of the amygdala.Neuroscience · 2012Article
- Article
- A selective interplay between aberrant EPSPKA and INaP reduces spike timing precision in dentate granule cells of epileptic rats.Cerebral cortex (New York, N.Y. : 1991) · 2010Article
- Perisomatic voltage-gated sodium channels actively maintain linear synaptic integration in principal neurons of the medial superior olive.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Intrinsic conductances actively shape excitatory and inhibitory postsynaptic responses in olfactory bulb external tufted cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Dopamine D1 receptor activation regulates sodium channel-dependent EPSP amplification in rat prefrontal cortex pyramidal neurons.The Journal of physiology · 2007Article
- Neural variability, detection thresholds, and information transmission in the vestibular system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Nonlinear information processing in a model sensory system.Journal of neurophysiology · 2006Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Intracellular recordings from hippocampal CA1 pyramidal neurones revealed that EPSPs evoked by selective stimulation of the isolated afferent input to the distal third of the apical dendrites were relatively insensitive to changes in dendritic membrane potential (Vm) but amplified by depolarizations of the somatic Vm. The amplification was present at potentials depolarized from resting membrane potential (RMP) but was most marked when the EPSPs were close to threshold for action potential generation. The amplification consisted of a uniform component and a variable component which was only present when the EPSPs were threshold straddling. 2. The somatic amplification was caused by an intrinsic membrane current which was blocked by somatic application of tetrodotoxin (TTX, 10 microM), but was insensitive to bath application of NiCl2 (100-200 microM). We therefore suggest that the amplification of the subthreshold EPSP is due primarily to the activation of a non-inactivating Na+ current (INaP). 3. Injection of 4-aminopyridine (4-AP, 25-50 mM) during intradendritic recordings resulted in amplification of the EPSPs in 37% of the dendrites, which was similar to that observed in somatic recordings. However, in the one case in which somatic application of TTX was tested, dendritic amplification was blocked, suggesting that it is a reflection of the somatic amplification. 4. Because the shift to variable amplification was very abrupt and it is present in only a very narrow voltage range close to threshold, we suggest that the variable component is caused by the regenerative activation of INaP. The variability itself is probably due to the simultaneous activation of different outward K+ currents. 5. The present results indicate that the somatic region of CA1 pyramidal neurones can function as a voltage-dependent amplifier of distally evoked EPSPs and that this is due to the activation of a somatic INaP. The presence of this amplifying mechanism will have important functional consequences for the way in which distally generated EPSPs are integrated.
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