ReviewClinical & experimental metastasis1999
Are selectins involved in metastasis?
Review in Clinical & experimental metastasis, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 114 citations in OpenAlex.
- New specific molecular targets for radio-chemotherapy of rectal cancer.Molecular oncology · 2010Trial
- Glycomimetics for the inhibition and modulation of lectins.Chemical Society reviews · 2023Review
- Article
- Unlocking the therapeutic potential of artificial metalloenzymes.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2020Review
- The functional role of integrins during intra- and extravasation within the metastatic cascade.Molecular cancer · 2019Review
- Selectins in cancer immunity.Glycobiology · 2018Review
- Association of E-selectin S128R Polymorphism with Hereditary Breast Carcinoma Susceptibility in Turkish Patients WithoutBalkan journal of medical genetics : BJMG · 2018Article
- Protein glycosylation in cancers and its potential therapeutic applications in neuroblastoma.Journal of hematology & oncology · 2016Review
- Prognostic significance of ST3GAL-1 expression in patients with clear cell renal cell carcinoma.BMC cancer · 2015Article
- Cancer intelligence acquired (CIA): tumor glycosylation and sialylation codes dismantling antitumor defense.Cellular and molecular life sciences : CMLS · 2015Review
- Identification of Lectins from Metastatic Cancer Cells through Magnetic Glyconanoparticles.Israel journal of chemistry · 2015Article
- CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions.American journal of physiology. Cell physiology · 2015Article
- Chronic inflammation predisposing to cancer metastasis: lesson learned from a chronically embedded foreign body in a duodenal diverticulum.Journal of gastrointestinal cancer · 2014Article
- Inducing apoptosis in rolling cancer cells: a combined therapy with aspirin and immobilized TRAIL and E-selectin.Molecular pharmaceutics · 2012Article
- AB0 blood group and prognosis in patients with pancreatic cancer.BMC cancer · 2012Article
- E-selectin liposomal and nanotube-targeted delivery of doxorubicin to circulating tumor cells.Journal of controlled release : official journal of the Controlled Release Society · 2012Article
- Article
- Nanostructured Surfaces to Target and Kill Circulating Tumor Cells While Repelling Leukocytes.Journal of nanomaterials · 2012Article
- Article
- Sialylated Lewis x antigen bearing glycoproteins in human plasma.Journal of proteome research · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The selectins are a family of intercellular adhesion molecules that mediate the attachment of leukocytes to the endothelial lining of blood vessels. Another biological process that may involve selectins is the adhesion of circulating tumour cells to endothelium in cancer metastasis. This review discusses the evidence for the involvement of E-, P- and L-selectin in the metastasis of different tumour types. It is concluded that, with certain reservations and qualifications, selectins can play a role in metastasis. For example, the evidence for the involvement of E-selectin in breast and colon cancer metastasis is very strong. For the other selectins and tumour types the evidence is less convincing and further investigations are required to clarify the situation. Certainly, selectins are not the only mechanism available for tumours to metastasise. In the future, measurement of selectins could be useful prognostically and manipulation of their levels could lead to new cancer therapies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.