ArticleProceedings of the National Academy of Sciences of the United States of America1999
Protective effects of estrogen in a rat model of age-related cataracts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 77 citations in OpenAlex.
- Pooled it
- Aging of Nonhuman Primate Eyes Is Sexually Dimorphic.Investigative ophthalmology & visual science · 2026Article
- Association of Alpha-Crystallin with Human Cortical and Nuclear Lens Lipid Membrane Increases with the Grade of Cortical and Nuclear Cataract.International journal of molecular sciences · 2024Article
- Hysterectomy for Benign Indications and Risk of Cataract Formation in South Korean Women.Medicina (Kaunas, Lithuania) · 2023Article
- Correlation of neuter status and expression of heritable disorders.Canine genetics and epidemiology · 2017Article
- Development of topical ophthalmic In Situ gel-forming estradiol delivery system intended for the prevention of age-related cataracts.PloS one · 2017Article
- Is Estrogen a Therapeutic Target for Glaucoma?Seminars in ophthalmology · 2016Review
- Etiopathogenesis of cataract: an appraisal.Indian journal of ophthalmology · 2014Review
- 17β-estradiol eye drops protect the retinal ganglion cell layer and preserve visual function in an in vivo model of glaucoma.Molecular pharmaceutics · 2013Article
- High affinity nuclear and nongenomic estradiol binding sites in the human and mouse lens.Experimental eye research · 2013Article
- Estrogen mediated protection of cytoskeleton against oxidative stress.The Indian journal of medical research · 2013Article
- Genistein and genistein-containing dietary supplements accelerate the early stages of cataractogenesis in the male ICR/f rat.Experimental eye research · 2011Article
- Effects of 17β-estradiol on proliferation, cell viability and intracellular redox status in native human lens epithelial cells.Molecular vision · 2011Article
- Polymorphisms in steroidogenesis genes, sex steroid levels, and high myopia in the Taiwanese population.Molecular vision · 2011Article
- Effect of estrogen replacement therapy on lens epithelial cell apoptosis in an experimental rat model.International ophthalmology · 2010Article
- Estrogen protects against radiation-induced cataractogenesis.Radiation research · 2008Article
- The prevalence and demographic characteristics of anterior polar cataract in a hospital-based study in Korea.Korean journal of ophthalmology : KJO · 2008Article
- Mitochondrial superoxide dismutase activation with 17 beta-estradiol-treated human lens epithelial cells.Molecular vision · 2008Article
- Characterizing a rat Brca2 knockout model.Oncogene · 2007Article
- Diethylstilbestrol increases intracellular calcium in lens epithelial cells.Pflugers Archiv : European journal of physiology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Women have a higher incidence of cataracts, and epidemiologic data suggest that the increased risk may be caused by a lack of estrogen in postmenopausal years. We have examined the effects of estrogen on methylnitrosourea (MNU)-induced cataractogenesis in Sprague-Dawley rats. Animals were ovariectomized, injected with MNU, and treated with estradiol or estrone by a continuous-release, subcutaneous Silastic implant, or they received an empty Silastic implant (no hormone). In the no-hormone group, rats developed opaque lenses approximately 6 months after MNU treatment. By 8 months, 74% (14/19) of the no-hormone rats had evident opacity in one or both eyes by simple gross inspection; 58% (22/38) of the eyes in this group were opaque. Estradiol or estrone treatment reduced the incidence of cataractous eyes to 12% or 25%, respectively. Lenses were examined under a dissecting microscope for light transmission. The lenses of the group treated with no hormone had light transmission of 26% +/- 9.2%, whereas lenses from the estradiol-treated animals had light transmission of 72% +/- 5.8%. Histological examination revealed that the anterior cortices of the opaque lenses were disrupted and showed the hallmark signs of age-related cataracts; in addition, some eyes that appeared clear by macroscopic examination showed the early histologic signs of cataractogenesis. It was demonstrated with reverse transcription-PCR that lens cells express both alpha and beta types of estrogen receptor, suggesting that the protective effects of the hormones may be a direct, receptor-mediated phenomenon. Thus, the MNU-treated, ovariectomized rat serves as a model for age-related cataractogenesis, and observation of a clear protective effect of estrogens in this system supports the implications of epidemiologic data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.