ArticleProceedings of the National Academy of Sciences of the United States of America1999
Heme oxygenase induction mediates the photoimmunoprotective activity of UVA radiation in the mouse.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 111 citations in OpenAlex.
- The role and safety of UVA and UVB in UV-induced skin erythema.Frontiers in medicine · 2023Article
- UVA Radiation, DNA Damage, and Melanoma.ACS omega · 2022Review
- Photoaging: UV radiation-induced inflammation and immunosuppression accelerate the aging process in the skin.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Review
- Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions.Biomolecules · 2021Review
- Pharmacological Modulation of Nrf2/HO-1 Signaling Pathway as a Therapeutic Target of Parkinson's Disease.Frontiers in pharmacology · 2021Review
- Heme Oxygenases: Cellular Multifunctional and Protective Molecules against UV-Induced Oxidative Stress.Oxidative medicine and cellular longevity · 2019Review
- Autophagy: Multiple Mechanisms to Protect Skin from Ultraviolet Radiation-Driven Photoaging.Oxidative medicine and cellular longevity · 2019Review
- Immune Relevant and Immune Deficient Mice: Options and Opportunities in Translational Research.ILAR journal · 2018Review
- Role of heme Oxygenase-1 in low dose Radioadaptive response.Redox biology · 2016Article
- Novel vitamin D compounds and skin cancer prevention.Dermato-endocrinology · 2013Review
- Postischemic cardiac recovery in heme oxygenase-1 transgenic ischemic/reperfused mouse myocardium.Journal of cellular and molecular medicine · 2011Article
- Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Interstitial lung disease and pulmonary hypertension responsive to low-dose ultraviolet A1 irradiation in lupus.Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases · 2010Article
- Carbon monoxide signalling reduces photocarcinogenesis in the hairless mouse.Cancer immunology, immunotherapy : CII · 2007Article
- What is a role of haeme oxygenase-1 in psoriasis? Current concepts of pathogenesis.International journal of experimental pathology · 2007Review
- Estrogen receptor signaling protects against immune suppression by UV radiation exposure.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Anomalous renal effects of tin protoporphyrin in a murine model of sickle cell disease.The American journal of pathology · 2006Article
- Heat shock protein 32 in human peripheral blood mononuclear cells: effect of aging and inflammation.Journal of clinical immunology · 2005Article
- The role of heme oxygenase signaling in various disorders.Molecular and cellular biochemistry · 2002Review
- Lack of metallothionein-I and -II exacerbates the immunosuppressive effect of ultraviolet B radiation and cis-urocanic acid in mice.Immunology · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In contrast to the immunosuppressive potential of UVB (280-320 nm) radiation in experimental animals and humans, UVA (320-400 nm) radiation at environmentally relevant doses appears to be immunologically inert. However, such exposure to UVA radiation has been observed unexpectedly to induce resistance to UVB-induced immunosuppression in mice, by a mechanism resulting in the inactivation of cis-urocanic acid (UCA), an epidermal immunosuppressive UV photoproduct. In this study in mice, we show that the immunoprotective activity of UVA radiation, against the effects of both UVB radiation and cis-UCA, can be attributed to the induction of cutaneous heme oxygenase (HO; EC 1.14.99.3). Cell-mediated immune function was assessed in vivo by the contact hypersensitivity response induced to oxazolone at an unirradiated skin site, and HO enzyme activity was measured in cutaneous microsomal preparations from treated mice. There was a progressive increase in HO enzyme activity for at least 3 days after UVA irradiation. However HO activity, both constitutive and UVA radiation-induced, was sensitive to the effects of injecting mice with the specific HO inhibitor, tin protoporphyrin (Sn [IV] protoporphyrin IX; SnPP). We observed, in addition, that in SnPP-injected mice, the immunoprotective effect of UVA radiation against either UVB radiation or cis-UCA was abrogated. Because SnPP injection did not affect normal contact hypersensitivity responsiveness but did inhibit the constitutive HO enzyme activity, it appeared that only the inducible HO was active in modulating immune function. This finding indicates that UVA-induced HO activity is a major player in the skin defenses against UVB immunosuppression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.