ArticleProceedings of the National Academy of Sciences of the United States of America1999
A comparison of T cell memory against the same antigen induced by virus versus intracellular bacteria.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Pilot study of an HLA-A2 peptide vaccine using flt3 ligand as a systemic vaccine adjuvant.Journal of clinical immunology · 2003Trial
- The Virological, Immunological, and Imaging Approaches for COVID-19 Diagnosis and Research.SLAS technology · 2020Review
- Dissolving Microneedle Patches for Dermal Vaccination.Pharmaceutical research · 2017Review
- Evaluation of Aggregated Ag85B Antigen for Its Biophysical Properties, Immunogenicity, and Vaccination Potential in a Murine Model of Tuberculosis Infection.Frontiers in immunology · 2017Article
- Homeostatic division is not necessary for antigen-specific CD4+ memory T cell persistence.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Role of sustained antigen release from nanoparticle vaccines in shaping the T cell memory phenotype.Biomaterials · 2012Article
- Article
- CD4 memory T cells: what are they and what can they do?Seminars in immunology · 2009Review
- Memory T-lymphocyte survival does not require T-cell receptor expression.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- TIPE2, a negative regulator of innate and adaptive immunity that maintains immune homeostasis.Cell · 2008Article
- Secondary memory CD8+ T cells are more protective but slower to acquire a central-memory phenotype.The Journal of experimental medicine · 2006Article
- Maintenance of long-term tumour-specific T-cell memory by residual dormant tumour cells.Immunology · 2005Article
- RNA encoding the MPT83 antigen induces protective immune responses against Mycobacterium tuberculosis infection.Infection and immunity · 2004Article
- Protection from bacterial infection by a single vaccination with replication-deficient mutant herpes simplex virus type 1.Journal of virology · 2004Article
- Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia.Immunity · 2003Article
- Preexisting inflammation due to Mycobacterium bovis BCG infection differentially modulates T-cell priming against a replicating or nonreplicating immunogen.Infection and immunity · 2002Article
- Dissecting the complexity of the memory T cell response.Immunologic research · 2002Review
- Protective long-term antibody memory by antigen-driven and T help-dependent differentiation of long-lived memory B cells to short-lived plasma cells independent of secondary lymphoid organs.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Requirements for bone marrow-derived antigen-presenting cells in priming cytotoxic T cell responses to intracellular pathogens.The Journal of experimental medicine · 2000Article
- Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Cytotoxic T cell (CTL) memory was analyzed after infection with lymphocytic choriomeningitis virus (LCMV) and recombinant Listeria monocytogenes (rLM) expressing the complete nucleoprotein of LCMV (rLM-NP(actA)) or only the immunodominant epitope of H-2(d) mice (rLM-NP(118-126)). Immunization with LCMV and rLM induced a long-lived increased CTL precursor (CTLp) frequency specific for the viral (NP(118-126)) and for the bacterial (LLO(91-99)) epitope, respectively. However, after infection with rLM memory, CTLs were less protective against an intravenous LCMV challenge infection than a comparable number of LCMV-induced memory T cells. LCMV, but not recombinant Listeria-induced memory T cells were able to protect against lethal choriomeningitis by LCMV or a subsequent peripheral infection with recombinant vaccinia virus expressing LCMV-NP. The protective memory after viral and after rLM immunization was paralleled by evidence of LCMV but not rLM antigen persistence on day 15 and 30 after vaccination. These results document a striking difference in protective T cell memory between viral and bacterial vaccines and indicate that rapid T cell-dependent immune protection correlates with antigen persistence.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.