ArticleProceedings of the National Academy of Sciences of the United States of America1999
High expression of a specific T-cell receptor gamma transcript in epithelial cells of the prostate.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 67 citations in OpenAlex.
- γδ T Cells in Brain Homeostasis and Diseases.Frontiers in immunology · 2022Review
- TARP as antigen in cancer immunotherapy.Cancer immunology, immunotherapy : CII · 2021Review
- The Potential Role for Immunotherapy in Biochemically Recurrent Prostate Cancer.The Urologic clinics of North America · 2020Review
- TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment.Haematologica · 2020Article
- Clinical Significance ofHemaSphere · 2020Article
- TARP vaccination is associated with slowing in PSA velocity and decreasing tumor growth rates in patients with Stage D0 prostate cancer.Oncoimmunology · 2016Article
- Laser capture microdissection: Big data from small samples.Histology and histopathology · 2015Review
- Molecular characterization of the feline T-cell receptor γ alternate reading frame protein (TARP) ortholog.Journal of veterinary science · 2012Article
- T cells engineered with a T cell receptor against the prostate antigen TARP specifically kill HLA-A2+ prostate and breast cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Strategies to use immune modulators in therapeutic vaccines against cancer.Seminars in oncology · 2012Review
- Review
- Antibody responses to galectin-8, TARP and TRAP1 in prostate cancer patients treated with a GM-CSF-secreting cellular immunotherapy.Cancer immunology, immunotherapy : CII · 2010Article
- Non-AUG translational initiation of a short CAPC transcript generating protein isoform.Biochemical and biophysical research communications · 2009Article
- Targeting TARP, a novel breast and prostate tumor-associated antigen, with T cell receptor-like human recombinant antibodies.European journal of immunology · 2008Article
- High expression of a cytokeratin-associated protein in many cancers.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
- NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Discovery of the breast cancer gene BASE using a molecular approach to enrich for genes encoding membrane and secreted proteins.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
We have identified expression of T-cell receptor gamma chain (TCRgamma) mRNA in human prostate and have shown that it originates from epithelial cells of the prostate and not from infiltrating T-lymphocytes. In contrast, the T-cell receptor delta chain (TCRdelta) gene is silent in human prostate. The major TCRgamma transcript in prostate has a different size than the transcript expressed in thymus, spleen, and blood leukocytes. It is expressed in normal prostate epithelium, adenocarcinoma of the prostate, and the prostatic adenocarcinoma cell line LNCaP. The RNA originates from an unrearranged TCRgamma locus, and it is initiated within the intronic sequence directly upstream of the Jgamma1.2 gene segment. The prostate-specific TCRgamma transcript consists of the Jgamma1.2 and Cgamma1 gene segments, and it has an untranslated sequence including a polyadenylation signal and poly(A) sequence at the 3'end. The finding that prostate epithelial cells express a high level of a transcript from a gene that was thought to by exclusively expressed by T-lymphocytes is highly unexpected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.