ArticleProceedings of the National Academy of Sciences of the United States of America1999
Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 157 citations in OpenAlex.
- The core genetic drivers of chronological aging in yeast are universal regulators of longevity.Microbial cell (Graz, Austria) · 2025Article
- Multi-Omics Profiling ofMicroorganisms · 2023Article
- Mitochondria reorganization upon proliferation arrest predicts individual yeast cell fate.eLife · 2018Article
- The role of autophagy in the regulation of yeast life span.Annals of the New York Academy of Sciences · 2018Review
- Yeast quiescence exit swiftness is influenced by cell volume and chronological age.Microbial cell (Graz, Austria) · 2017Article
- Dietary restriction and lifespan: Lessons from invertebrate models.Ageing research reviews · 2017Review
- Aggregation of the Whi3 protein, not loss of heterochromatin, causes sterility in old yeast cells.Science (New York, N.Y.) · 2017Article
- Unbalanced Growth, Senescence and Aging.Advances in experimental medicine and biology · 2017Review
- Quantitative proteomic comparison of stationary/G0 phase cells and tetrads in budding yeast.Scientific reports · 2016Article
- Similar environments but diverse fates: Responses of budding yeast to nutrient deprivation.Microbial cell (Graz, Austria) · 2016Article
- Condensin and Hmo1 Mediate a Starvation-Induced Transcriptional Position Effect within the Ribosomal DNA Array.Cell reports · 2016Article
- Biochemical Genetic Pathways that Modulate Aging in Multiple Species.Cold Spring Harbor perspectives in medicine · 2015Review
- Article
- The many ways to age for a single yeast cell.Yeast (Chichester, England) · 2014Review
- Links between nucleolar activity, rDNA stability, aneuploidy and chronological aging in the yeast Saccharomyces cerevisiae.Biogerontology · 2014Article
- Longevity pathways and maintenance of the proteome: the role of autophagy and mitophagy during yeast ageing.Microbial cell (Graz, Austria) · 2014Review
- Early manifestations of replicative aging in the yeastMicrobial cell (Graz, Austria) · 2014Article
- Article
- Quasi-programmed aging of budding yeast: a trade-off between programmed processes of cell proliferation, differentiation, stress response, survival and death defines yeast lifespan.Cell cycle (Georgetown, Tex.) · 2014Review
- Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae.Experimental gerontology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Saccharomyces cerevisiae mother cells undergo an aging program that includes morphologic changes, sterility, redistribution of the Sir transcriptional silencing complex from HM loci and telomeres to the nucleolus, alterations in nucleolar architecture, and accumulation of extrachromosomal ribosomal DNA circles (ERCs). We report here that cells starved for nutrients during prolonged periods in stationary phase show a decrease in generational lifespan when they reenter the cell cycle. This shortened lifespan is not transmitted to progeny cells, indicating that it is not due to irreversible genetic damage. The decrease in the lifespan is accompanied by all of the changes of accelerated aging with the notable exception that ERC accumulation is not augmented compared with generation-matched, nonstarved cells. These results suggest a number of models, including one in which starvation reveals a component of aging that works in parallel with the accumulation of ERCs. Stationary-phase yeast cells may be a useful system for identifying factors that affect aging in other nondividing eukaryotic cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.