ArticleProceedings of the National Academy of Sciences of the United States of America1999
Enhancement of translation by the downstream box does not involve base pairing of mRNA with the penultimate stem sequence of 16S rRNA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 101 citations in OpenAlex.
- Recent Advances in Archaeal Translation Initiation.Frontiers in microbiology · 2020Review
- Cold-Responsive Regions of Paradigm Cold-Shock and Non-Cold-Shock mRNAs Responsible for Cold Shock Translational Bias.International journal of molecular sciences · 2019Article
- Noncanonical Translation Initiation Comes of Age.Journal of bacteriology · 2017Article
- Initiation of mRNA translation in bacteria: structural and dynamic aspects.Cellular and molecular life sciences : CMLS · 2015Review
- Translation initiation: variations in the mechanism can be anticipated.Cellular and molecular life sciences : CMLS · 2011Review
- Follow the leader: preference for specific amino acids directly following the initial methionine in proteins of different organisms.Genomics, proteomics & bioinformatics · 2010Article
- Dynamic evolution of translation initiation mechanisms in prokaryotes.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Saturation mutagenesis of a +1 programmed frameshift-inducing mRNA sequence derived from a yeast retrotransposon.RNA (New York, N.Y.) · 2007Article
- Interaction between the ribosomal subunits: 16S rRNA suppressors of the lethal DeltaA1916 mutation in the 23S rRNA of Escherichia coli.Molecular genetics and genomics : MGG · 2007Article
- Efficient expression of gene variants that harbour AGA codons next to the initiation codon.Nucleic acids research · 2007Article
- Naturally occurring adenines within mRNA coding sequences affect ribosome binding and expression in Escherichia coli.Journal of bacteriology · 2007Article
- Predicting Shine-Dalgarno sequence locations exposes genome annotation errors.PLoS computational biology · 2006Article
- Highly expressed proteins have an increased frequency of alanine in the second amino acid position.BMC genomics · 2006Article
- Development of novel types of plastid transformation vectors and evaluation of factors controlling expression.Transgenic research · 2005Article
- Initiation of protein synthesis in bacteria.Microbiology and molecular biology reviews : MMBR · 2005Review
- A codon window in mRNA downstream of the initiation codon where NGG codons give strongly reduced gene expression in Escherichia coli.Nucleic acids research · 2004Article
- Translation initiation with 70S ribosomes: an alternative pathway for leaderless mRNAs.Nucleic acids research · 2004Article
- An unusual internal ribosomal entry site of inverted symmetry directs expression of a potato leafroll polerovirus replication-associated protein.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Evolutionary conservation of reactions in translation.Microbiology and molecular biology reviews : MMBR · 2002Review
- Protein S1 counteracts the inhibitory effect of the extended Shine-Dalgarno sequence on translation.RNA (New York, N.Y.) · 2002Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The downstream box (DB) is a sequence element that enhances translation of several bacterial and phage mRNAs. It has been proposed that the DB enhances translation by base pairing transiently to bases 1469-1483 of 16S rRNA, the so-called anti-DB, during the initiation phase of translation. We have tested this model of enhancer action by constructing mutations in the anti-DB that alter its mRNA base-pairing potential and examining expression of a variety of DB-containing mRNAs in strains expressing the mutant anti-DB 16S rRNA. We found that the rRNA mutant was viable and that expression of all tested DB-containing mRNAs was completely unaffected by radical alterations in the proposed anti-DB. These findings lead us to conclude that enhancement of translation by the DB does not involve mRNA-rRNA base pairing.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.