ArticleGenetics1999
A new mouse insertional mutation that causes sensorineural deafness and vestibular defects.
Article in Genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme.BMC biology · 2022Article
- Congenital Deafness and Recent Advances Towards Restoring Hearing Loss.Current protocols · 2021Article
- KCNK5 channels mostly expressed in cochlear outer sulcus cells are indispensable for hearing.Nature communications · 2015Article
- Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Genetics of hearing and deafness.Anatomical record (Hoboken, N.J. : 2007) · 2012Review
- The sound of silence: mouse models for hearing loss.Genetics research international · 2011Article
- Proteomics, bioinformatics and targeted gene expression analysis reveals up-regulation of cochlin and identifies other potential biomarkers in the mouse model for deafness in Usher syndrome type 1F.Human molecular genetics · 2010Article
- The micromachinery of mechanotransduction in hair cells.Annual review of neuroscience · 2007Review
- A new spontaneous mutation in the mouse protocadherin 15 gene.Hearing research · 2006Article
- Progression of inner ear pathology in Ames waltzer mice and the role of protocadherin 15 in hair cell development.Journal of the Association for Research in Otolaryngology : JARO · 2006Article
- Characterization of vestibular dysfunction in the mouse model for Usher syndrome 1F.Journal of the Association for Research in Otolaryngology : JARO · 2005Article
- The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.Molecular cell · 2000Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
This article describes a new recessive insertional mutation in the transgenic line TgN2742Rpw that causes deafness and circling behavior in mice. Histologic analysis revealed virtually complete loss of the cochlear neuroepithelium (the organ of Corti) in adult mutant mice. In association with the neuroepithelial changes, there is a dramatic reduction of the cochlear nerve supply. Adult mutants also show morphological defects of the vestibular apparatus, including degeneration of the saccular neuroepithelium and occasional malformation of utricular otoconia. Audiometric evaluations demonstrated that the mice displaying the circling phenotype are completely deaf. Molecular analysis of this mutant line revealed that the transgenic insertion occurred without creating a large deletion of the host DNA sequences. The mutant locus was mapped to a region on mouse chromosome 10, where other spontaneous, recessive mutations causing deafness in mice have been mapped.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.